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Ctr9 Ctr9 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38149, updated on 9-Dec-2024

Summary

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Official Symbol
Ctr9provided by FlyBase
Official Full Name
Ctr9provided by FlyBase
Primary source
FLYBASE:FBgn0035205
Locus tag
Dmel_CG2469
See related
AllianceGenome:FB:FBgn0035205
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg2469; CG2469; dCtr9; Dmel\CG2469
Summary
Predicted to enable RNA polymerase II complex binding activity and SH2 domain binding activity. Involved in germ cell development; negative regulation of neuroblast proliferation; and regulation of gene expression. Predicted to be located in euchromatin. Predicted to be part of Cdc73/Paf1 complex. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Orthologous to human CTR9 (CTR9 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ctr9 in Genome Data Viewer
Location:
61F5-61F6; 3-0 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1307224..1311805)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1307224..1311805)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Rac1 Neighboring gene Acetyl-CoA acetyltransferase 2 Neighboring gene 5' nucleotidase A Neighboring gene sturkopf Neighboring gene HECT and RLD domain containing E3 ubiquitin ligase 4 Neighboring gene Myosin 61F Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila CG2469 Encodes a Homolog of Human CTR9 and Is Essential for Development. Chaturvedi D, et al. G3 (Bethesda), 2016 Dec 7. PMID 27678520, Free PMC Article
  2. Role of the Paf1 complex in the maintenance of stem cell pluripotency and development. Park J, et al. FEBS J, 2023 Feb. PMID 35869661
  3. Parafibromin governs cell polarity and centrosome assembly in Drosophila neural stem cells. Deng Q, et al. PLoS Biol, 2022 Oct. PMID 36223339, Free PMC Article
  4. Dosage sensitivity and exon shuffling shape the landscape of polymorphic duplicates in Drosophila and humans. Zhang D, et al. Nat Ecol Evol, 2022 Mar. PMID 34969986
  5. PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters. Gerlach JM, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29078288, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH2 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ventral cord development HMP PubMed 
Component Evidence Code Pubs
part_of Cdc73/Paf1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in euchromatin ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Ctr9
Names
CG2469-PA
CG2469-PB
Ctr9-PA
Ctr9-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1307224..1311805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176271.2 → NP_788449.1  Ctr9, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788449.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0X3
    Related
    FBpp0072561
    Conserved Domains (4) summary
    sd00006
    Location:306 → 334
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:344 → 374
    TPR_1; Tetratricopeptide repeat
    pfam08424
    Location:400 → 532
    NRDE-2; NRDE-2, necessary for RNA interference
    pfam13414
    Location:166 → 228
    TPR_11; TPR repeat

  2. NM_176270.2 → NP_788448.1  Ctr9, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788448.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0X3
    Related
    FBpp0072562
    Conserved Domains (4) summary
    sd00006
    Location:306 → 334
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:344 → 374
    TPR_1; Tetratricopeptide repeat
    pfam08424
    Location:400 → 532
    NRDE-2; NRDE-2, necessary for RNA interference
    pfam13414
    Location:166 → 228
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K0X3 Q7K0X3

Gene LinkOut

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