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Fam178b family with sequence similarity 178, member B [ Mus musculus (house mouse) ]

Gene ID: 381337, updated on 4-Jan-2025

Summary

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Official Symbol
Fam178bprovided by MGI
Official Full Name
family with sequence similarity 178, member Bprovided by MGI
Primary source
MGI:MGI:3026913
See related
Ensembl:ENSMUSG00000046337 AllianceGenome:MGI:3026913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm990; 1700024G10Rik
Summary
Orthologous to human FAM178B (family with sequence similarity 178 member B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward testis adult (RPKM 99.4) See more
Orthologs
human all
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Genomic context

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See Fam178b in Genome Data Viewer
Location:
1 B; 1 15.33 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36601779..36722271, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36562696..36683190, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 23 Neighboring gene STARR-positive B cell enhancer ABC_E320 Neighboring gene ankyrin repeat domain 39 Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C Neighboring gene STARR-seq mESC enhancer starr_00646 Neighboring gene STARR-positive B cell enhancer ABC_E1539 Neighboring gene cytochrome c oxidase subunit 5B Neighboring gene ARP1 actin-related protein 1B, centractin beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC60970, MGC141033

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein FAM178B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126046.2 → NP_001119518.1  protein FAM178B isoform A

    Status: VALIDATED

    Source sequence(s)
    AC084389, AC084391
    Consensus CDS
    CCDS48241.1
    UniProtKB/Swiss-Prot
    Q24JP3, Q3URT9, Q80VJ7, Q9DA00
    UniProtKB/TrEMBL
    E9PXB2
    Related
    ENSMUSP00000132846.2, ENSMUST00000170295.8
    Conserved Domains (1) summary
    pfam14816
    Location:76 → 382
    FAM178; Family of unknown function, FAM178

  2. NM_001372416.1 → NP_001359345.1  protein FAM178B isoform D

    Status: VALIDATED

    Description
    Transcript Variant: This variant (D) represents the longest transcript and encodes the longest isoform (D).
    Source sequence(s)
    AC084389, AC084391
    Conserved Domains (1) summary
    pfam14816
    Location:73 → 480
    FAM178; Family of unknown function, FAM178

  3. NM_001372417.1 → NP_001359346.1  protein FAM178B isoform E

    Status: VALIDATED

    Source sequence(s)
    AC084389, AC084391
    UniProtKB/Swiss-Prot
    Q24JP3, Q3URT9, Q80VJ7, Q9DA00
    UniProtKB/TrEMBL
    A0AAQ4VMR2
    Related
    ENSMUSP00000159961.1, ENSMUST00000249865.1
    Conserved Domains (1) summary
    pfam14816
    Location:73 → 426
    FAM178; Family of unknown function, FAM178

  4. NM_027957.2 → NP_082233.1  protein FAM178B isoform B

    See identical proteins and their annotated locations for NP_082233.1

    Status: VALIDATED

    Source sequence(s)
    AC084391
    UniProtKB/Swiss-Prot
    Q24JP3
    Related
    ENSMUST00000193763.6

  5. NM_201365.3 → NP_958753.2  protein FAM178B isoform C

    Status: VALIDATED

    Source sequence(s)
    AC084389
    Consensus CDS
    CCDS14885.2
    UniProtKB/TrEMBL
    A0AAQ4VMR4, E9PUL8
    Related
    ENSMUSP00000124023.2, ENSMUST00000114981.3
    Conserved Domains (1) summary
    pfam14816
    Location:76 → 365
    FAM178; Family of unknown function, FAM178

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    36601779..36722271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321446.2 → XP_017176935.1  protein FAM178B isoform X3

    UniProtKB/Swiss-Prot
    Q24JP3, Q3URT9, Q80VJ7, Q9DA00
    Conserved Domains (1) summary
    pfam14816
    Location:73 → 439
    FAM178; Family of unknown function, FAM178

  2. XM_006496116.3 → XP_006496179.1  protein FAM178B isoform X2

    See identical proteins and their annotated locations for XP_006496179.1

    UniProtKB/Swiss-Prot
    Q24JP3, Q3URT9, Q80VJ7, Q9DA00
    Conserved Domains (1) summary
    pfam14816
    Location:73 → 442
    FAM178; Family of unknown function, FAM178

  3. XM_017321439.2 → XP_017176928.1  protein FAM178B isoform X1

    Conserved Domains (1) summary
    pfam14816
    Location:73 → 480
    FAM178; Family of unknown function, FAM178

  4. XM_030255205.1 → XP_030111065.1  protein FAM178B isoform X6

    Conserved Domains (1) summary
    pfam14816
    Location:1 → 176
    FAM178; Family of unknown function, FAM178

  5. XM_036166197.1 → XP_036022090.1  protein FAM178B isoform X6

    Conserved Domains (1) summary
    pfam14816
    Location:1 → 176
    FAM178; Family of unknown function, FAM178

  6. XM_036166198.1 → XP_036022091.1  protein FAM178B isoform X7

    Conserved Domains (1) summary
    pfam14816
    Location:1 → 230
    FAM178; Family of unknown function, FAM178

  7. XM_017321452.3 → XP_017176941.1  protein FAM178B isoform X8

    Conserved Domains (1) summary
    pfam14816
    Location:1 → 91
    FAM178; Family of unknown function, FAM178

  8. XM_011238555.4 → XP_011236857.1  protein FAM178B isoform X9

    See identical proteins and their annotated locations for XP_011236857.1

    UniProtKB/Swiss-Prot
    Q24JP3

  9. XM_006496122.5 → XP_006496185.1  protein FAM178B isoform X9

    See identical proteins and their annotated locations for XP_006496185.1

    UniProtKB/Swiss-Prot
    Q24JP3
    Related
    ENSMUST00000193548.6

  10. XM_017321449.2 → XP_017176938.1  protein FAM178B isoform X4

    UniProtKB/TrEMBL
    A0AAQ4VMR4
    Conserved Domains (1) summary
    pfam14816
    Location:73 → 462
    FAM178; Family of unknown function, FAM178

  11. XM_017321451.1 → XP_017176940.1  protein FAM178B isoform X5

    Conserved Domains (1) summary
    pfam14816
    Location:73 → 368
    FAM178; Family of unknown function, FAM178
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24JP3.2 GenPept UniProtKB/Swiss-Prot:Q24JP3

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