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Tmem232 transmembrane protein 232 [ Mus musculus (house mouse) ]

Gene ID: 381107, updated on 27-Nov-2024

Summary

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Official Symbol
Tmem232provided by MGI
Official Full Name
transmembrane protein 232provided by MGI
Primary source
MGI:MGI:2685786
See related
Ensembl:ENSMUSG00000045036 AllianceGenome:MGI:2685786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm940; Tes13-L; Tes13-S; E130009J12Rik
Summary
Involved in flagellated sperm motility and spermatogenesis. Acts upstream of or within maintenance of protein complex location and spermatid cytoplasm removal during spermiation of flagellated sperm. Is active in outer dense fiber. Orthologous to human TMEM232 (transmembrane protein 232). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 15.4) See more
Orthologs
human all
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Genomic context

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See Tmem232 in Genome Data Viewer
Location:
17 E1.1; 17 34.9 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (65562994..65848080, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65255999..65541082, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43005 Neighboring gene predicted gene, 49865 Neighboring gene STARR-seq mESC enhancer starr_43006 Neighboring gene enolase 1, alpha non-neuron pseudogene Neighboring gene STARR-seq mESC enhancer starr_43009 Neighboring gene STARR-seq mESC enhancer starr_43010 Neighboring gene hypoxanthine guanine phosphoribosyl transferase pseudogene Neighboring gene predicted gene 9288 Neighboring gene STARR-seq mESC enhancer starr_43012 Neighboring gene mitochondrial ribosomal protein S10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43013 Neighboring gene predicted gene, 53984 Neighboring gene ribosomal protein L18 pseudogene Neighboring gene predicted gene, 35400 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice. He X, et al. Cells, 2023 Jun 13. PMID 37371084, Free PMC Article
  2. TMEM232 promotes the inflammatory response in atopic dermatitis via the nuclear factor-κB and signal transducer and activator of transcription 3 signalling pathways. Han J, et al. Br J Dermatol, 2023 Jul 17. PMID 36928730
  3. TRF2-mediated telomere protection is dispensable in pluripotent stem cells. Markiewicz-Potoczny M, et al. Nature, 2021 Jan. PMID 33239785, Free PMC Article
  4. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM232 promotes the inflammatory response in atopic dermatitis via the nuclear factor-kappaB and signal transducer and activator of transcription 3 signalling pathways.
    Title: TMEM232 promotes the inflammatory response in atopic dermatitis via the nuclear factor-κB and signal transducer and activator of transcription 3 signalling pathways.
  2. Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice.
    Title: Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maintenance of protein complex location IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maintenance of protein complex location IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in spermatid cytoplasm removal during spermiation of flagellated sperm IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatid cytoplasm removal during spermiation of flagellated sperm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in outer dense fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in outer dense fiber IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 232
Names
testis-specific protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008973.2 → NP_001008973.2  transmembrane protein 232 isoform a

    See identical proteins and their annotated locations for NP_001008973.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AF338469, BB538070, BB618060, CAAA01027226, DV662151
    Consensus CDS
    CCDS28940.1
    UniProtKB/Swiss-Prot
    B2RX35, B7ZWG2, Q5K6N0, Q5K6N1
    Related
    ENSMUSP00000083927.4, ENSMUST00000086722.10
    Conserved Domains (1) summary
    pfam15877
    Location:40 → 488
    TMEM232; Transmembrane protein family 232

  2. NM_001289485.1 → NP_001276414.1  transmembrane protein 232 isoform a

    See identical proteins and their annotated locations for NP_001276414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    BB618060, BC150885, BX638107, CT030729
    Consensus CDS
    CCDS28940.1
    UniProtKB/Swiss-Prot
    B2RX35, B7ZWG2, Q5K6N0, Q5K6N1
    Related
    ENSMUSP00000055652.7, ENSMUST00000062161.7
    Conserved Domains (1) summary
    pfam15877
    Location:40 → 488
    TMEM232; Transmembrane protein family 232

  3. NM_001289486.1 → NP_001276415.1  transmembrane protein 232 isoform b

    See identical proteins and their annotated locations for NP_001276415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. It encodes a shorter isoform (b), compared to isoform a.
    Source sequence(s)
    BB618060, BC172032, BX638107
    Consensus CDS
    CCDS89134.1
    UniProtKB/Swiss-Prot
    Q5K6N0
    Related
    ENSMUSP00000156833.2, ENSMUST00000233117.2
    Conserved Domains (1) summary
    pfam15877
    Location:40 → 487
    TMEM232; Transmembrane protein family 232

  4. NM_001360185.1 → NP_001347114.1  transmembrane protein 232 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC154457, AC154821, CT030729
    Consensus CDS
    CCDS89135.1
    Related
    ENSMUSP00000156513.2, ENSMUST00000233738.2
    Conserved Domains (2) summary
    pfam15877
    Location:7 → 454
    TMEM232; Transmembrane protein family 232
    cl25602
    Location:551 → 626
    DUF3552; Domain of unknown function (DUF3552)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    65562994..65848080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524493.4 → XP_006524556.1  transmembrane protein 232 isoform X2

    UniProtKB/TrEMBL
    A0A3B2W4C3
    Related
    ENSMUSP00000156859.2, ENSMUST00000233328.2
    Conserved Domains (2) summary
    pfam15877
    Location:1 → 372
    TMEM232; Transmembrane protein family 232
    pfam18654
    Location:483 → 552
    LegC3_N; LegC3 N-terminal coiled-coil domain

  2. XM_006524492.4 → XP_006524555.1  transmembrane protein 232 isoform X1

    Conserved Domains (2) summary
    pfam15877
    Location:40 → 402
    TMEM232; Transmembrane protein family 232
    pfam18654
    Location:513 → 582
    LegC3_N; LegC3 N-terminal coiled-coil domain

  3. XM_030249871.1 → XP_030105731.1  transmembrane protein 232 isoform X3

    Conserved Domains (2) summary
    pfam15877
    Location:7 → 368
    TMEM232; Transmembrane protein family 232
    pfam18654
    Location:479 → 548
    LegC3_N; LegC3 N-terminal coiled-coil domain

RNA

  1. XR_004939547.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5K6N0.2 GenPept UniProtKB/Swiss-Prot:Q5K6N0

Gene LinkOut

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