Cyp2d12 cytochrome P450, family 2, subfamily d, polypeptide 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2d12provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily d, polypeptide 12provided by MGI
Primary source: MGI:MGI:88604
See related: Ensembl:ENSMUSG00000096852 AllianceGenome:MGI:88604
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9030605E09Rik
Summary: Predicted to enable anandamide epoxidase activity; aromatase activity; and heme binding activity. Predicted to be involved in arachidonate metabolic process and xenobiotic metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 25.1), kidney adult (RPKM 22.9) and 2 other tissues See more
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Genomic context

Location:: 15 E1; 15 38.64 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (82439244..82443614)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (82555043..82559413)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables anandamide 11,12 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables anandamide 14,15 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables anandamide 8,9 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables aromatase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450, family 2, subfamily d, polypeptide 12

Names: cytochrome P450, 2d12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355665.1 → NP_001342594.1 cytochrome P450, family 2, subfamily d, polypeptide 12 isoform 2

Status: VALIDATED

Source sequence(s)

AC132878

Consensus CDS

CCDS88815.1

UniProtKB/TrEMBL

B7ZP10, D3Z6U9

Related

ENSMUSP00000154856.2, ENSMUST00000229904.2

Conserved Domains (1) summary

pfam00067
Location:37 → 445

p450; Cytochrome P450
NM_201360.2 → NP_958748.1 cytochrome P450, family 2, subfamily d, polypeptide 12 isoform 1

See identical proteins and their annotated locations for NP_958748.1

Status: VALIDATED

Source sequence(s)

AC132878

Consensus CDS

CCDS37160.1

UniProtKB/TrEMBL

Q8BVD2

Related

ENSMUSP00000071064.7, ENSMUST00000068861.8

Conserved Domains (1) summary

pfam00067
Location:37 → 496

p450; Cytochrome P450