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Mrs2 MRS2 magnesium transporter [ Mus musculus (house mouse) ]

Gene ID: 380836, updated on 27-Nov-2024

Summary

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Official Symbol
Mrs2provided by MGI
Official Full Name
MRS2 magnesium transporterprovided by MGI
Primary source
MGI:MGI:2685748
See related
Ensembl:ENSMUSG00000021339 AllianceGenome:MGI:2685748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HPT; RPT; Gm902; Mrs2l
Summary
Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in lactate metabolic process and mitochondrial magnesium ion transmembrane transport. Located in mitochondrion. Orthologous to human MRS2 (magnesium transporter MRS2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 14.1), colon adult (RPKM 13.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mrs2 in Genome Data Viewer
Location:
13 A3.1; 13 10.83 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (25171466..25204345, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (24987483..25020363, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene glycosylphosphatidylinositol specific phospholipase D1 Neighboring gene predicted gene, 34019 Neighboring gene microRNA 12184 Neighboring gene predicted gene, 52042 Neighboring gene STARR-positive B cell enhancer mm9_chr13:25142251-25142552 Neighboring gene STARR-seq mESC enhancer starr_33992 Neighboring gene doublecortin domain containing 2a Neighboring gene STARR-seq mESC enhancer starr_33993 Neighboring gene neurensin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Limiting Mrs2-dependent mitochondrial Mg(2+) uptake induces metabolic programming in prolonged dietary stress. Madaris TR, et al. Cell Rep, 2023 Mar 28. PMID 36857182, Free PMC Article
  2. Mice Lacking Mrs2 Magnesium Transporter are Hypophagic and Thin When Maintained on a High-Fat Diet. Powell DR, et al. Endocrinology, 2024 Jul 1. PMID 38878275
  3. Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca(2+) uptake and viability. Ponnusamy T, et al. Mitochondrion, 2024 May. PMID 38599304
  4. ERMA (TMEM94) is a P-type ATPase transporter for Mg(2+) uptake in the endoplasmic reticulum. Vishnu N, et al. Mol Cell, 2024 Apr 4. PMID 38513662,
  5. Lactate Elicits ER-Mitochondrial Mg(2+) Dynamics to Integrate Cellular Metabolism. Daw CC, et al. Cell, 2020 Oct 15. PMID 33035451, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mice Lacking Mrs2 Magnesium Transporter are Hypophagic and Thin When Maintained on a High-Fat Diet.
    Title: Mice Lacking Mrs2 Magnesium Transporter are Hypophagic and Thin When Maintained on a High-Fat Diet.
  2. Limiting Mrs2-dependent mitochondrial Mg[2+] uptake induces metabolic programming in prolonged dietary stress.
    Title: Limiting Mrs2-dependent mitochondrial Mg(2+) uptake induces metabolic programming in prolonged dietary stress.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lactate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lactate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial magnesium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial magnesium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial magnesium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
magnesium transporter MRS2 homolog, mitochondrial
Names
MRS2 magnesium homeostasis factor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013389.2 → NP_001013407.2  magnesium transporter MRS2 homolog, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001013407.2

    Status: VALIDATED

    Source sequence(s)
    AL645533, AW456688, BB015377, BU058305, CA752560
    Consensus CDS
    CCDS26385.2
    UniProtKB/Swiss-Prot
    Q5NCE8
    Related
    ENSMUSP00000021772.4, ENSMUST00000021772.4
    Conserved Domains (1) summary
    cd12823
    Location:79 → 390
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    25171466..25204345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516707.5 → XP_006516770.2  magnesium transporter MRS2 homolog, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd12823
    Location:79 → 351
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5NCE8.2 GenPept UniProtKB/Swiss-Prot:Q5NCE8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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