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gol goliath [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38006, updated on 9-Dec-2024

Summary

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Official Symbol
golprovided by FlyBase
Official Full Name
goliathprovided by FlyBase
Primary source
FLYBASE:FBgn0004919
Locus tag
Dmel_CG2679
See related
AllianceGenome:FB:FBgn0004919
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-G1; CG2679; dgol; Dmel\CG2679; g1; Gol; meso
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in mesoderm formation and protein ubiquitination. Located in endosome. Is expressed in several structures, including dorsal pharyngeal muscle primordium; larval muscle system; pharyngeal muscle cell; somatic muscle primordium; and visceral muscle primordium. Orthologous to several human genes including RNF150 (ring finger protein 150). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See gol in Genome Data Viewer
Location:
60F3-60F3; 2-107 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (25072627..25084347, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20960150..20971870, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene gooseberry-neuro Neighboring gene transfer RNA:Alanine-CGC 1-1 Neighboring gene transfer RNA:Alanine-CGC 1-2 Neighboring gene transfer RNA:Alanine-CGC 1-3 Neighboring gene gooseberry Neighboring gene jim lovell Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila melanogaster developmental gene g1 encodes a variant zinc-finger-motif protein. Bouchard ML, et al. Gene, 1993 Mar 30. PMID 8462875
  2. From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease. Cabana VC, et al. Cells, 2022 Jan 23. PMID 35159190, Free PMC Article
  3. The gooseberry-zipper region of Drosophila: five genes encode different spatially restricted transcripts in the embryo. Côté S, et al. EMBO J, 1987 Sep. PMID 16453795, Free PMC Article
  4. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Miller JP, et al. Neuron, 2010 Jul 29. PMID 20670829, Free PMC Article
  5. Codon usage affects the structure and function of the Drosophila circadian clock protein PERIOD. Fu J, et al. Genes Dev, 2016 Aug 1. PMID 27542830, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in mesoderm formation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
goliath
Names
CG2679-PB
CG2679-PC
CG2679-PD
CG2679-PE
gol-PB
gol-PC
gol-PD
gol-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    25072627..25084347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169829.3 → NP_001163300.1  goliath, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163300.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q06003
    Conserved Domains (3) summary
    cd02122
    Location:73 → 217
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    pfam13639
    Location:301 → 344
    zf-RING_2; Ring finger domain
    cl11506
    Location:226 → 258
    UPF0233; uncharacterized protein family (UPF0233)

  2. NM_166705.3 → NP_726508.1  goliath, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726508.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JGX0, Q06003, Q8T0M7, Q9W0W3
    Related
    FBpp0072361
    Conserved Domains (3) summary
    cd02122
    Location:73 → 217
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    pfam13639
    Location:301 → 344
    zf-RING_2; Ring finger domain
    cl11506
    Location:226 → 258
    UPF0233; uncharacterized protein family (UPF0233)

  3. NM_001259588.2 → NP_001246517.1  goliath, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246517.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K8B7
    Conserved Domains (3) summary
    cd02122
    Location:73 → 217
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    pfam13639
    Location:301 → 344
    zf-RING_2; Ring finger domain
    cl11506
    Location:226 → 258
    UPF0233; uncharacterized protein family (UPF0233)

  4. NM_079140.5 → NP_523864.3  goliath, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523864.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K8B7
    Conserved Domains (3) summary
    cd02122
    Location:73 → 217
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    pfam13639
    Location:301 → 344
    zf-RING_2; Ring finger domain
    cl11506
    Location:226 → 258
    UPF0233; uncharacterized protein family (UPF0233)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K8B7 A0A0B4K8B7
Q06003.3 Q06003

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