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CG3770 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37991, updated on 4-Jan-2025

Summary

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Official Symbol
CG3770provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035085
Locus tag
Dmel_CG3770
See related
AllianceGenome:FB:FBgn0035085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CT12588; Dmel\CG3770
Summary
Predicted to be located in septate junction. Predicted to be active in membrane. Orthologous to human LHFPL2 (LHFPL tetraspan subfamily member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG3770 in Genome Data Viewer
Location:
60E8-60E8; 2-107 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24945139..24946636)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20832662..20834159)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Troponin C-akin-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44830

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control. Nelson KS, et al. Genetics, 2010 Jul. PMID 20407131, Free PMC Article
  2. Organization and function of the blood-brain barrier in Drosophila. Stork T, et al. J Neurosci, 2008 Jan 16. PMID 18199760, Free PMC Article
  3. Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control. Wu VM, et al. J Cell Biol, 2004 Jan 19. PMID 14734539, Free PMC Article
  4. Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. Shulman JM, et al. Am J Hum Genet, 2011 Feb 11. PMID 21295279, Free PMC Article
  5. A Drosophila RNAi screen reveals conserved glioblastoma-related adhesion genes that regulate collective cell migration. Kotian N, et al. G3 (Bethesda), 2022 Jan 4. PMID 34849760, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
NOT involved_in establishment of glial blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in septate junction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG3770-PA
CG3770-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24945139..24946636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138141.3 → NP_611985.2  uncharacterized protein Dmel_CG3770, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611985.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SW9, Q9W0X9
    Related
    FBpp0072300
    Conserved Domains (1) summary
    pfam10242
    Location:10 → 195
    L_HGMIC_fpl; Lipoma HMGIC fusion partner-like protein

  2. NM_001299935.1 → NP_001286864.1  uncharacterized protein Dmel_CG3770, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286864.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SW9, Q9W0X9
    Conserved Domains (1) summary
    pfam10242
    Location:10 → 195
    L_HGMIC_fpl; Lipoma HMGIC fusion partner-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95SW9 Q95SW9
Q9W0X9 Q9W0X9

Gene LinkOut

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