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snai1.S snail family zinc finger 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379615, updated on 4-Jan-2025

Summary

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Official Symbol
snai1.S
Official Full Name
snail family zinc finger 1 S homeolog
Primary source
Xenbase:XB-GENE-865328
See related
EnsemblRapid:ENSXLAG00005035311 AllianceGenome:Xenbase:XB-GENE-865328
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
sna; xSna; snai1; Xsnail; snail1; snai1.L
Summary
Is expressed in ectoderm; nervous system; pharyngeal arch; and vestibuloauditory system. Orthologous to human SNAI1 (snail family transcriptional repressor 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See snai1.S in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
3
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (10596604..10600534, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (10472699..10476629, complement)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene sodium/hydrogen exchanger 8-like Neighboring gene ubiquitin conjugating enzyme E2 variant 1 L homeolog Neighboring gene ring finger protein 114 L homeolog Neighboring gene spermatogenesis associated 2 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PAPC mediates self/non-self-distinction during Snail1-dependent tissue separation. Luu O, et al. J Cell Biol, 2015 Mar 16. PMID 25778923, Free PMC Article
  2. Identification in Xenopus of a structural homologue of the Drosophila gene snail. Sargent MG, et al. Development, 1990 Aug. PMID 2226210
  3. Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation. Lander R, et al. Nat Commun, 2013. PMID 23443570, Free PMC Article
  4. The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1. Lander R, et al. J Cell Biol, 2011 Jul 11. PMID 21727196, Free PMC Article
  5. An estimate of the sequencing error frequency in the DNA sequence databases. Kristensen T, et al. DNA Seq, 1992. PMID 1446073

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transcription factor Snail1 is essential for tissue separation, enabling paraxial protocadherin (PAPC) to promote tissue separation through novel functions.
    Title: PAPC mediates self/non-self-distinction during Snail1-dependent tissue separation.
  2. Interaction with Snail1/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.
    Title: Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation.
  3. the same E3 ubiquitin ligase known to regulate Snail family proteins, Partner of paired (Ppa), also controlled Twist stability and did so in a manner dependent on the Twist WR-rich domain
    Title: The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC64552

General protein information

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Preferred Names
protein snail homolog Sna
Names
protein Xsnail
protein xSna
snail family zinc finger 1 L homeolog
snail homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086456.1 → NP_001079925.1  protein snail homolog Sna

    Status: PROVISIONAL

    Source sequence(s)
    BC056857
    UniProtKB/Swiss-Prot
    P19382, Q5PRF8
    Related
    ENSXLAP00005105645.1, ENSXLAT00005107704.1
    Conserved Domains (5) summary
    COG5048
    Location:173 → 249
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178 → 198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:121 → 141
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204 → 226
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:191 → 214
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    10596604..10600534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19382.1 GenPept UniProtKB/Swiss-Prot:P19382

Gene LinkOut

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Molecular Biology Databases
Research Materials