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Mid1 Mid1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37953, updated on 9-Dec-2024

Summary

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Official Symbol
Mid1provided by FlyBase
Official Full Name
Mid1provided by FlyBase
Primary source
FLYBASE:FBgn0053988
Locus tag
Dmel_CG33988
See related
AllianceGenome:FB:FBgn0053988
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13595; cg13596; CG13596; CG18510; CG33988; Dmel\CG33988; mid1; Nlf-1
Summary
Contributes to leak channel activity. Involved in locomotor rhythm and social behavior. Part of cation channel complex. Is expressed in dorsal ectoderm; ganglia; sensory cluster; ventral ectoderm; and ventral nerve cord primordium. Orthologous to human NALF1 (NALCN channel auxiliary factor 1) and NALF2 (NALCN channel auxiliary factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Mid1 in Genome Data Viewer
Location:
60D14-60D16; 2-107 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24695378..24736657, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20582901..20624180, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Painting of fourth Neighboring gene Matrix metalloproteinase 1 Neighboring gene Sialyltransferase Neighboring gene long non-coding RNA:CR44828 Neighboring gene Ubiquitin specific protease 15/31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Narrow Abdomen Ion Channel Complex Is Highly Stable and Persists from Development into Adult Stages to Promote Behavioral Rhythmicity. Moose DL, et al. Front Cell Neurosci, 2017. PMID 28634443, Free PMC Article
  2. New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN. Monteil A, et al. Physiol Rev, 2024 Jan 1. PMID 37615954
  3. A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability. Flourakis M, et al. Cell, 2015 Aug 13. PMID 26276633, Free PMC Article
  4. Ancient association between cation leak channels and Mid1 proteins is conserved in fungi and animals. Ghezzi A, et al. Front Mol Neurosci, 2014. PMID 24639627, Free PMC Article
  5. Light/Clock Influences Membrane Potential Dynamics to Regulate Sleep States. Tabuchi M, et al. Front Neurol, 2021. PMID 33854471, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to leak channel activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
contributes_to stretch-activated, monoatomic cation-selective, calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhythmic behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cation channel complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Mid1
Names
CG33988-PA
CG33988-PB
Mid1 ortholog
Mid1-PA
Mid1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24695378..24736657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274241.1 → NP_001261170.1  Mid1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261170.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWK9, Q9I7V0
    Conserved Domains (1) summary
    pfam12929
    Location:651 → 676
    Mid1; Stretch-activated Ca2+-permeable channel component

  2. NM_001038883.2 → NP_001033972.1  Mid1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033972.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWK9, Q9I7V0
    Conserved Domains (1) summary
    pfam12929
    Location:651 → 676
    Mid1; Stretch-activated Ca2+-permeable channel component
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I7V0 Q9I7V0

Gene LinkOut

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