pax2.L paired box 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pax2.L
Official Full Name: paired box 2 L homeolog
Primary source: Xenbase:XB-GENE-486805
Locus tag: XELAEV_18034870mg
See related: EnsemblRapid:ENSXLAG00005029297 AllianceGenome:Xenbase:XB-GENE-486805
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: pax2; XPax2; pax-2; Pax-2a; XPax-2; pax2-a; pax2-b; xPax-2a
Summary: Predicted to enable DNA binding activity. Acts upstream of or within thyroid gland development. Predicted to be located in nucleus. Is expressed in several structures, including endocrine system; mesenchyme; nervous system; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 7; renal Wilms' tumor; and renal coloboma syndrome. Orthologous to human PAX2 (paired box 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 7L

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7L	NC_054383.1 (40853246..40915774)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7L	NC_030736.1 (38375866..38435692)

Chromosome 7L - NC_054383.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pax2 is required after the establishment of the tubule pronephric anlage, for the expression of several terminal differentiation markers of the pronephric tubule.
Title: Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development.
pax2 transcription factor cooperates in patterning the Xenopus brain.
Title: En2, Pax2/5 and Tcf-4 transcription factors cooperate in patterning the Xenopus brain.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within segment polarity determination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thyroid gland development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within thyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: paired box protein Pax-2-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086361.1 → NP_001079830.1 paired box protein Pax-2-A

See identical proteins and their annotated locations for NP_001079830.1

Status: PROVISIONAL

Source sequence(s)

Y10121

UniProtKB/TrEMBL

O57676

Related

ENSXLAP00005087864.1, ENSXLAT00005089526.1

Conserved Domains (3) summary

smart00351
Location:16 → 140

PAX; Paired Box domain

pfam12403
Location:282 → 425

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:232 → 255

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.