Nurf-38 Nucleosome remodeling factor - 38kD [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nurf-38provided by FlyBase
Official Full Name: Nucleosome remodeling factor - 38kDprovided by FlyBase
Primary source: FLYBASE:FBgn0016687
Locus tag: Dmel_CG4634
See related: AllianceGenome:FB:FBgn0016687
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 38; CG4634; Dmel\CG4634; dNURF; l(2)k16102; N38; NURF; Nurf 38; NURF 38; NURF-38; Nurf38; NURF38; p38; p38/NURF-38; PPA1
Summary: Enables inorganic diphosphate phosphatase activity. Involved in nucleosome organization; positive regulation of transcription by RNA polymerase II; and regulation of hemocyte proliferation. Located in cytoplasm and nucleus. Part of NURF complex. Is expressed in adult head; adult heart; organism; and spermatozoon. Orthologous to human PPA1 (inorganic pyrophosphatase 1) and PPA2 (inorganic pyrophosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 60D5-60D5; 2-107 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24558967..24561087, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20446490..20448610, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The current study further solidified the role of STAT and Wg in regeneration, by identifying their contribution to abnormal regenerations induced by IR. STAT92E (Drosophila STAT3/5) and Nurf-38, which encodes a member of the Nucleosome Remodeling Factor complex, oppose each other in these cells to modulate the frequency of ectopic disc growth
Title: STAT, Wingless, and Nurf-38 determine the accuracy of regeneration after radiation damage in Drosophila.
results suggest that the ISWI-containing NURF complex functions as a co-activator of Armadillo to promote Wg-mediated transcription.
Title: The ISWI-containing NURF complex regulates the output of the canonical Wingless pathway.
sliding model in which the position-specific tethering of NURF forces a translocating ISWI ATPase to pump a DNA distortion over the histone octamer, thereby changing the translational position of the nucleosome.
Title: Spatial contacts and nucleosome step movements induced by the NURF chromatin remodeling complex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables inorganic diphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inorganic diphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables inorganic diphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleosome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphate-containing compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NURF complex	IDA Inferred from Direct Assay more info	PubMed
part_of NURF complex	IPI Inferred from Physical Interaction more info	PubMed
part_of NURF complex	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nucleosome remodeling factor - 38kD

Names: CG4634-PA; CG4634-PB; CG4634-PC; Nurf-38-PA; Nurf-38-PB; Nurf-38-PC; inorganic pyrophosphatase; inorganic pyrophosphatase 1; nucleosome remodeling factor; nucleosome remodeling factor-38 kDa; pyrophosphatase

NP_001137758.1

EC 3.6.1.1

NP_001246494.1

EC 3.6.1.1

NP_523849.3

EC 3.6.1.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24558967..24561087 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079125.3 → NP_523849.3 nucleosome remodeling factor - 38kD, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523849.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O77460, Q9W150

UniProtKB/TrEMBL

I0DHK6

Related

FBpp0072250

Conserved Domains (1) summary

cl00217
Location:26 → 292

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
NM_001144286.3 → NP_001137758.1 nucleosome remodeling factor - 38kD, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137758.1

Status: REVIEWED

UniProtKB/TrEMBL

B7YZQ7, B9EQY3

Conserved Domains (1) summary

cl00217
Location:4 → 244

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
NM_001259565.2 → NP_001246494.1 nucleosome remodeling factor - 38kD, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246494.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7G9, B9EQY3

Conserved Domains (1) summary

cl00217
Location:4 → 244

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.