U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Brca2 BRCA2, DNA repair associated [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37916, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Brca2provided by FlyBase
Official Full Name
BRCA2, DNA repair associatedprovided by FlyBase
Primary source
FLYBASE:FBgn0050169
Locus tag
Dmel_CG30169
See related
AllianceGenome:FB:FBgn0050169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
30169; BcDNA:SD25109; brca; brca2; BRCA2; CG13583; CG13584; CG30169; dmbrca2; Dmbrca2; Dmel\CG30169
Summary
Involved in DNA synthesis involved in DNA repair; meiotic recombination checkpoint signaling; and response to camptothecin. Located in nucleus. Is expressed in organism. Used to study 46 XX gonadal dysgenesis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Brca2 in Genome Data Viewer
Location:
60D4-60D4; 2-107 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24526172..24529581)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20413695..20417104)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 60f Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 60e Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A fragmented alignment method detects a putative phosphorylation site and a putative BRC repeat in the Drosophila melanogaster BRCA2 protein. Chakraborty S. F1000Res, 2013. PMID 24627786, Free PMC Article
  2. Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2. Bennett SM, et al. PLoS One, 2010 Jun 8. PMID 20543987, Free PMC Article
  3. Essential Role of BRCA2 in Ovarian Development and Function. Weinberg-Shukron A, et al. N Engl J Med, 2018 Sep 13. PMID 30207912, Free PMC Article
  4. Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2. Thomas AM, et al. G3 (Bethesda), 2013 Jan. PMID 23316441, Free PMC Article
  5. Annealing of Complementary DNA Sequences During Double-Strand Break Repair in Drosophila Is Mediated by the Ortholog of SMARCAL1. Holsclaw JK, et al. Genetics, 2017 May. PMID 28258182, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. persistent meiotic DNA double-strand breaks might correspond to crossovers, which are mobilized to the nuclear envelope for their repair; Brca2-Pds5 complexes may be key mediators of this process.
    Title: Brca2-Pds5 complexes mobilize persistent meiotic recombination sites to the nuclear envelope.
  2. A mutation in Cyp6d2, a cytochrome P450 gene, when combined with a brca2 mutation, resulted in synergistic hypersensitivity to camptothecin.
    Title: Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2.
  3. DNA repair by homologous recombination is dramatically decreased in CG30169 (brca2 homolog) mutants.
    Title: Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA synthesis involved in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic DNA repair synthesis involved in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic recombination checkpoint signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in meiotic recombination checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to camptothecin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
BRCA2, DNA repair associated
Names
Brca2-PA
CG30169-PA
breast cancer 2 early onset homolog
breast cancer 2, early onset homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24526172..24529581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138081.4 → NP_611925.2  BRCA2, DNA repair associated [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611925.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B2CPK7, B2CPK8, Q494G5, Q8MRU0, Q9W157
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W157.3 Q9W157

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools