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arhgap29b Rho GTPase activating protein 29b [ Danio rerio (zebrafish) ]

Gene ID: 378998, updated on 9-Dec-2024

Summary

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Official Symbol
arhgap29bprovided by ZNC
Official Full Name
Rho GTPase activating protein 29bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031010-44
See related
Ensembl:ENSDARG00000017748 AllianceGenome:ZFIN:ZDB-GENE-031010-44
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
arhgap29; sb:cb905; zgc:63950
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; pectoral fin bud; pectoral fin musculature; periderm; and tail bud. Orthologous to human ARHGAP29 (Rho GTPase activating protein 29). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See arhgap29b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (15128398..15197920)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (15459542..15529330)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene coagulation factor IIIb Neighboring gene ATP-binding cassette, sub-family D (ALD), member 3b Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 4b Neighboring gene trans-2,3-enoyl-CoA reductase-like 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation. Letelier J, et al. Proc Natl Acad Sci U S A, 2018 Apr 17. PMID 29610331, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 29
Names
Rho GTPase activating protein 29
rho-type GTPase-activating protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200111.2 → NP_956405.2  rho GTPase-activating protein 29

    Status: VALIDATED

    Source sequence(s)
    CR450809
    UniProtKB/Swiss-Prot
    Q6PCS4
    Related
    ENSDARP00000115452.1, ENSDART00000141921.3
    Conserved Domains (3) summary
    smart00109
    Location:677 → 723
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd04409
    Location:735 → 945
    RhoGAP_PARG1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also ...
    cl12013
    Location:253 → 466
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    15128398..15197920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163312.5 → XP_005163369.1  rho GTPase-activating protein 29 isoform X1

    UniProtKB/Swiss-Prot
    Q6PCS4
    UniProtKB/TrEMBL
    A0A8M2BAB9
    Conserved Domains (3) summary
    smart00109
    Location:677 → 723
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd04409
    Location:735 → 945
    RhoGAP_PARG1; RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts ...
    cl12013
    Location:253 → 466
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_005163314.5 → XP_005163371.1  rho GTPase-activating protein 29 isoform X2

    UniProtKB/Swiss-Prot
    Q6PCS4
    UniProtKB/TrEMBL
    A0A8M2BAG0
    Conserved Domains (3) summary
    smart00109
    Location:671 → 717
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd04409
    Location:729 → 939
    RhoGAP_PARG1; RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts ...
    cl12013
    Location:247 → 460
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_005163315.5 → XP_005163372.1  rho GTPase-activating protein 29 isoform X3

    UniProtKB/Swiss-Prot
    Q6PCS4
    UniProtKB/TrEMBL
    A0A8M2BAH9
    Conserved Domains (3) summary
    smart00109
    Location:501 → 547
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd04409
    Location:559 → 769
    RhoGAP_PARG1; RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts ...
    cl12013
    Location:77 → 290
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PCS4.1 GenPept UniProtKB/Swiss-Prot:Q6PCS4

Gene LinkOut

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