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CG3376 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37884, updated on 9-Dec-2024

Summary

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Official Symbol
CG3376provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034997
Locus tag
Dmel_CG3376
See related
AllianceGenome:FB:FBgn0034997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aSMase; Dmel\CG3376
Summary
Predicted to enable sphingomyelin phosphodiesterase activity. Involved in liquid clearance, open tracheal system. Located in extracellular space and lysosome. Is expressed in several structures, including embryonic epipharynx; embryonic head epidermis; epithelium; gut section; and larval muscle cell. Human ortholog(s) of this gene implicated in Niemann-Pick disease; Niemann-Pick disease type A; and Niemann-Pick disease type B. Orthologous to human SMPD1 (sphingomyelin phosphodiesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG3376 in Genome Data Viewer
Location:
60C4-60C4; 2-106 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24258013..24265213)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20145536..20152736)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene nord Neighboring gene Ionotropic receptor 60a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nervy

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila. Chen X, et al. Natl Sci Rev, 2022 Dec. PMID 36713590, Free PMC Article
  2. CLOCKWORK ORANGE promotes CLOCK-CYCLE activation via the putative Drosophila ortholog of CLOCK INTERACTING PROTEIN CIRCADIAN. Rivas GBS, et al. Curr Biol, 2021 Oct 11. PMID 34331859, Free PMC Article
  3. A surfactant lipid layer of endosomal membranes facilitates airway gas filling in Drosophila. Tsarouhas V, et al. Curr Biol, 2023 Dec 4. PMID 37992718
  4. An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms. Kanca O, et al. Elife, 2019 Nov 1. PMID 31674908, Free PMC Article
  5. Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. Renault AD, et al. Mech Dev, 2002 Dec. PMID 14516700

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acid sphingomyelin phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables sphingomyelin phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in liquid clearance, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingomyelin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingomyelin catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG3376-PA
CG3376-PB
CG3376-PC
CG3376-PD
NP_001246491.1
NP_001286833.1
NP_611904.1
NP_726435.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24258013..24265213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166665.2 → NP_726435.1  uncharacterized protein Dmel_CG3376, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726435.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MLP3
    Related
    FBpp0072172
    Conserved Domains (3) summary
    smart00741
    Location:157 → 229
    SapB; Saposin (B) Domains
    cd00842
    Location:272 → 571
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
    pfam00149
    Location:270 → 534
    Metallophos; Calcineurin-like phosphoesterase

  2. NM_001299904.1 → NP_001286833.1  uncharacterized protein Dmel_CG3376, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286833.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGL2
    Conserved Domains (3) summary
    smart00741
    Location:157 → 229
    SapB; Saposin (B) Domains
    cd00842
    Location:272 → 571
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
    pfam00149
    Location:270 → 534
    Metallophos; Calcineurin-like phosphoesterase

  3. NM_138060.3 → NP_611904.1  uncharacterized protein Dmel_CG3376, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611904.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W188
    Related
    FBpp0072173
    Conserved Domains (3) summary
    smart00741
    Location:157 → 229
    SapB; Saposin (B) Domains
    cd00842
    Location:272 → 571
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
    pfam00149
    Location:270 → 534
    Metallophos; Calcineurin-like phosphoesterase

  4. NM_001259562.1 → NP_001246491.1  uncharacterized protein Dmel_CG3376, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246491.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D6W4U0
    Conserved Domains (3) summary
    smart00741
    Location:186 → 258
    SapB; Saposin (B) Domains
    cd00842
    Location:301 → 600
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
    pfam00149
    Location:299 → 563
    Metallophos; Calcineurin-like phosphoesterase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGL2 A0A0B4LGL2
D6W4U0 D6W4U0
Q8MLP3 Q8MLP3
Q95T74 Q95T74
Q9W188 Q9W188

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