drd2l dopamine receptor D2 like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: drd2lprovided by ZNC
Official Full Name: dopamine receptor D2 likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030910-1
See related: Ensembl:ENSDARG00000014858 AllianceGenome:ZFIN:ZDB-GENE-030910-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: drd2b
Summary: Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of glutamatergic synaptic transmission; and regulation of dopamine secretion. Predicted to act upstream of or within G protein-coupled dopamine receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in glutamatergic synapse and presynaptic membrane. Is expressed in brain and spinal cord. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (54248601..54291826)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (54390367..54433824)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha2-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables dopamine neurotransmitter receptor activity	IEA Inferred from Electronic Annotation more info
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled dopamine receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-inhibiting dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dopamine secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: dopamine receptor D2 like

Names: dopamine receptor D2b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_197935.1 → NP_922917.1 dopamine receptor D2 like

See identical proteins and their annotated locations for NP_922917.1

Status: PROVISIONAL

Source sequence(s)

AY333791

UniProtKB/TrEMBL

Q7T1A2

Related

ENSDARP00000023147.6, ENSDART00000002856.7

Conserved Domains (2) summary

pfam00001
Location:57 → 420

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:55 → 186

7tm_4; Olfactory receptor