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DnaJ-60 DnaJ-like-60 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37869, updated on 4-Jan-2025

Summary

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Official Symbol
DnaJ-60provided by FlyBase
Official Full Name
DnaJ-like-60provided by FlyBase
Primary source
FLYBASE:FBgn0260775
Locus tag
Dmel_CG42567
See related
AllianceGenome:FB:FBgn0260775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0172774.147; CG12240; CG42567; Dmel\CG42567; DmJ60; DnaJ60
Old locus tag
Dmel_CG12240
Summary
Predicted to enable unfolded protein binding activity. Involved in spermatogenesis. Predicted to be located in membrane. Is expressed in adult head. Orthologous to human DNAJC4 (DnaJ heat shock protein family (Hsp40) member C4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See DnaJ-60 in Genome Data Viewer
Location:
60C1-60C1; 2-106 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24157668..24159312, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20045191..20046835, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44826 Neighboring gene Zinc finger protein RP-8 Neighboring gene N(alpha)-acetyltransferase 35 Neighboring gene speck Neighboring gene uncharacterized protein Neighboring gene spaghetti Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The DnaJ60 gene of Drosophila melanogaster encodes a new member of the DnaJ family of proteins. Iliopoulos I, et al. Biol Chem, 1997 Oct. PMID 9372188
  2. Drosophila Spag is the homolog of RNA polymerase II-associated protein 3 (RPAP3) and recruits the heat shock proteins 70 and 90 (Hsp70 and Hsp90) during the assembly of cellular machineries. Benbahouche Nel H, et al. J Biol Chem, 2014 Feb 28. PMID 24394412, Free PMC Article
  3. Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates. Deo A, et al. Sci Rep, 2024 Sep 6. PMID 39242711, Free PMC Article
  4. Heat-shock promoters: targets for evolution by P transposable elements in Drosophila. Walser JC, et al. PLoS Genet, 2006 Oct 6. PMID 17029562, Free PMC Article
  5. RNAi-Mediated Reverse Genetic Screen Identified Drosophila Chaperones Regulating Eye and Neuromuscular Junction Morphology. Raut S, et al. G3 (Bethesda), 2017 Jul 5. PMID 28500055, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein refolding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to heat ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
DnaJ-like-60
Names
CG42567-PA
CG42567-PC
DnaJ-60-PA
DnaJ-60-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24157668..24159312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138048.3 → NP_611892.2  DnaJ-like-60, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611892.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P92029
    UniProtKB/TrEMBL
    Q8SZR5, Q9W1A1
    Conserved Domains (1) summary
    pfam00226
    Location:26 → 90
    DnaJ; DnaJ domain

  2. NM_079116.4 → NP_523840.1  DnaJ-like-60, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523840.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P92029
    UniProtKB/TrEMBL
    Q8SZR5, Q9W1A1
    Related
    FBpp0290486
    Conserved Domains (1) summary
    pfam00226
    Location:26 → 90
    DnaJ; DnaJ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P92029.1 P92029
Q8SZR5 Q8SZR5
Q9W1A1 Q9W1A1

Gene LinkOut

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