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enok enoki mushroom [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37859, updated on 4-Jan-2025

Summary

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Official Symbol
enokprovided by FlyBase
Official Full Name
enoki mushroomprovided by FlyBase
Primary source
FLYBASE:FBgn0034975
Locus tag
Dmel_CG11290
See related
AllianceGenome:FB:FBgn0034975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-60Ba; anon-WO0200864.1; anon-WO0200864.2; Cg11290; CG11290; Dmel\CG11290; dmHAG406; Enok; KAT6; rot; S1
Summary
Enables histone H3K23 acetyltransferase activity. Involved in several processes, including female germ-line stem cell population maintenance; nervous system development; and positive regulation of DNA-templated transcription. Part of MOZ/MORF histone acetyltransferase complex. Is expressed in spermatozoon; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in several diseases, including Arboleda-Tham syndrome; Ohdo syndrome, SBBYS variant; acute myeloid leukemia; bipolar disorder; and leiomyoma. Orthologous to several human genes including KAT6B (lysine acetyltransferase 6B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See enok in Genome Data Viewer
Location:
60B10-60B10; 2-106 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24099210..24107032)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19986733..19994555)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene something that sticks like glue Neighboring gene genghis khan Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. enok encodes a Drosophila putative histone acetyltransferase required for mushroom body neuroblast proliferation. Scott EK, et al. Curr Biol, 2001 Jan 23. PMID 11231125
  2. Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease. Bodai L, et al. Neurodegener Dis, 2012. PMID 21912091, Free PMC Article
  3. Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire. Huang F, et al. Genes Dev, 2014 Dec 15. PMID 25512562, Free PMC Article
  4. Effects of cadmium on fecundity and defence ability of Drosophila melanogaster. Hu X, et al. Ecotoxicol Environ Saf, 2019 Apr 30. PMID 30665104
  5. Acetyltransferase Enok regulates transposon silencing and piRNA cluster transcription. Tsai SY, et al. PLoS Genet, 2021 Feb. PMID 33524038, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok in Drosophila.
    Title: Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok in Drosophila.
  2. Acetyltransferase Enok regulates transposon silencing and piRNA cluster transcription.
    Title: Acetyltransferase Enok regulates transposon silencing and piRNA cluster transcription.
  3. Enok counteracts Polycomb group proteins-mediated repression and influences the ability of trithorax group proteins to maintain transcription of its target genes.
    Title: Genome-wide RNAi screen in Drosophila reveals Enok as a novel trithorax group regulator.
  4. Enok-mediated H3K23 acetylation (H3K23Ac) promotes the expression of spir, providing a specific mechanism linking oocyte polarization to histone modification.
    Title: Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire.
  5. Enok is required for maintaining GSCs non-autonomously.
    Title: The Drosophila putative histone acetyltransferase Enok maintains female germline stem cells through regulating Bruno and the niche.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K23 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in female germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of stem cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of piRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MOZ/MORF histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
enoki mushroom
Names
CG11290-PA
CG11290-PB
enok-PA
enok-PB
rotkehlchen
NP_001286823.1
NP_523838.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24099210..24107032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299894.1 → NP_001286823.1  enoki mushroom, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286823.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1A9
    Conserved Domains (6) summary
    pfam09528
    Location:1150 → 1539
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    smart00249
    Location:248 → 292
    PHD; PHD zinc finger
    pfam01853
    Location:768 → 947
    MOZ_SAS; MOZ/SAS family
    cl00073
    Location:95 → 152
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    cl17182
    Location:713 → 989
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    cl22851
    Location:183 → 215
    PHD_SF; PHD finger superfamily

  2. NM_079114.2 → NP_523838.1  enoki mushroom, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523838.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1A9
    Related
    FBpp0072159
    Conserved Domains (6) summary
    pfam09528
    Location:1150 → 1539
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    smart00249
    Location:248 → 292
    PHD; PHD zinc finger
    pfam01853
    Location:768 → 947
    MOZ_SAS; MOZ/SAS family
    cl00073
    Location:95 → 152
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    cl17182
    Location:713 → 989
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    cl22851
    Location:183 → 215
    PHD_SF; PHD finger superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TZ1 Q95TZ1
Q9W1A9 Q9W1A9

Gene LinkOut

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