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snama something that sticks like glue [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37857, updated on 9-Dec-2024

Summary

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Official Symbol
snamaprovided by FlyBase
Official Full Name
something that sticks like glueprovided by FlyBase
Primary source
FLYBASE:FBgn0086129
Locus tag
Dmel_CG3231
See related
AllianceGenome:FB:FBgn0086129
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD21643; BCDNA:LD21643; CG3231; Dmel\CG3231; FBgn0086129; l(2)rQ313; mnm; Snama; SNAMA
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in apoptotic process and cell proliferation involved in compound eye morphogenesis. Predicted to be active in nucleus. Is expressed in adult head; organism; primordial germ cell; and ventral furrow. Orthologous to human RBBP6 (RB binding protein 6, ubiquitin ligase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See snama in Genome Data Viewer
Location:
60B9-60B9; 2-106 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24086604..24092014)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19974127..19979537)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene genghis khan Neighboring gene enoki mushroom

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SNAMA, a novel protein with a DWNN domain and a RING finger-like motif: a possible role in apoptosis. Mather A, et al. Biochim Biophys Acta, 2005 Mar 10. PMID 15733535
  2. Glycolytic flux occurs in Drosophila melanogaster recovering from camptothecin treatment. Hull R, et al. Anticancer Drugs, 2010 Nov. PMID 20717003
  3. Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects. Kwon MJ, et al. Proc Natl Acad Sci U S A, 2018 Nov 6. PMID 30348793, Free PMC Article
  4. Competition within Introns: Splicing Wins over Polyadenylation via a General Mechanism. Tikhonov M, et al. Acta Naturae, 2013 Oct. PMID 24455183, Free PMC Article
  5. A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis. Deivasigamani S, et al. Biol Open, 2014 Oct 31. PMID 25361581, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two Snama transcripts differentially express during embryogenesis. The putative promoter has potential binding sites for transcription factors that are required for anteroposterior axis formation.
    Title: The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning.
  2. mnm as a regulator of mitotic progression during the proliferative phase of eye development, possibly through the control of nucleic acid metabolism
    Title: Characterization of Drosophila mini-me, a gene required for cell proliferation and survival.
  3. SNAMA a hitherto uncharacterized Drosophila protein that appears to play a role in apoptosis.
    Title: SNAMA, a novel protein with a DWNN domain and a RING finger-like motif: a possible role in apoptosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell proliferation involved in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
something that sticks like glue
Names
CG3231-PA
CG3231-PB
lethal (2) rQ313
mini-me
retinoblastoma binding protein 6 family
snama-PA
snama-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24086604..24092014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138040.4 → NP_611884.1  something that sticks like glue, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611884.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XZ21
    Related
    FBpp0072158
    Conserved Domains (4) summary
    COG5222
    Location:3 → 315
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00162
    Location:217 → 260
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam08783
    Location:3 → 75
    DWNN; DWNN domain
    pfam13696
    Location:148 → 167
    zf-CCHC_2; Zinc knuckle

  2. NM_001259558.2 → NP_001246487.1  something that sticks like glue, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246487.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D5SHU1
    Conserved Domains (4) summary
    COG5222
    Location:3 → 315
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00162
    Location:217 → 260
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam08783
    Location:3 → 75
    DWNN; DWNN domain
    pfam13696
    Location:148 → 167
    zf-CCHC_2; Zinc knuckle
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D5SHU1 D5SHU1
Q9XZ21 Q9XZ21

Gene LinkOut

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