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Galphas - G protein alpha subunit s

Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including positive regulation of feeding behavior; response to trehalose; and sensory perception of sweet taste. Located in basement membrane and plasma membrane. Part of heterotrimeric G-protein complex. Is active in neuromuscular junction; postsynapse; and presynapse. Is expressed in several structures, including chemosensory sensory organ; embryonic/larval midgut primordium; gut section; larval muscle cell; and organism subdivision. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; dystonia 25; pituitary adenoma 3; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Orthologous to several human genes including GNAL (G protein subunit alpha L). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa