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TM4SF Transmembrane 4 superfamily [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37786, updated on 4-Jan-2025

Summary

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Official Symbol
TM4SFprovided by FlyBase
Official Full Name
Transmembrane 4 superfamilyprovided by FlyBase
Primary source
FLYBASE:FBgn0020372
Locus tag
Dmel_CG11303
See related
AllianceGenome:FB:FBgn0020372
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11303; Dm.Tsp60A; Dmel\CG11303
Summary
Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; amnioserosa; embryonic/larval crystal cell; procrystal cell; and yolk nucleus. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; eye degenerative disease (multiple); and fundus albipunctatus. Orthologous to human PRPH2 (peripherin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See TM4SF in Genome Data Viewer
Location:
60A7-60A7; 2-105 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23878197..23880860)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19765720..19768383)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mitochondrial trifunctional protein beta subunit Neighboring gene ken and barbie Neighboring gene uncharacterized protein Neighboring gene Putative homeodomain protein Neighboring gene uncharacterized protein Neighboring gene Decapping protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane 4 superfamily
Names
CG11303-PA
CG11303-PB
CG11303-PC
TM4SF-PA
TM4SF-PB
TM4SF-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23878197..23880860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274230.1 → NP_001261159.1  transmembrane 4 superfamily, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261159.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFZ4, Q9UAI4
    Conserved Domains (2) summary
    cd03156
    Location:111 → 197
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9 → 224
    Tetraspannin; Tetraspanin family

  2. NM_001038879.2 → NP_001033968.1  transmembrane 4 superfamily, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033968.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2MGN3

  3. NM_057900.4 → NP_477248.1  transmembrane 4 superfamily, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477248.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76137, Q9UAI4
    Related
    FBpp0072039
    Conserved Domains (1) summary
    pfam00335
    Location:10 → 224
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFZ4 A0A0B4KFZ4
O76137 O76137
Q2MGN3 Q2MGN3
Q95SQ6 Q95SQ6
Q9UAI4 Q9UAI4

Gene LinkOut

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