KCNMA1 potassium calcium-activated channel subfamily M alpha 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KCNMA1provided by HGNC
Official Full Name: potassium calcium-activated channel subfamily M alpha 1provided by HGNC
Primary source: HGNC:HGNC:6284
See related: Ensembl:ENSG00000156113 MIM:600150; AllianceGenome:HGNC:6284
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SLO; BKTM; SLO1; hSlo; IEG16; LIWAS; MaxiK; PNKD3; SAKCA; mSLO1; CADEDS; KCa1.1; SLO-ALPHA; bA205K10.1
Summary: This gene encodes the alpha subunit of calcium-activated BK channel. The encoded protein is involved in several physiological processes including smooth muscle contraction, neurotransmitter release and neuronal excitability. Mutations in this gene are associated with a spectrum of neurological disorders including Paroxysmal Nonkinesigenic Dyskinesia 3, Idiopathic Generalized Epilepsy 16 and Liang-Wang syndrome. [provided by RefSeq, Aug 2022]
Expression: Broad expression in endometrium (RPKM 7.1), brain (RPKM 4.7) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q22.3

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (76869602..77637808, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (77738326..78506527, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (78629360..79397566, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evaluation of four KCNMA1 channelopathy variants on BK channel current under CaV1.2 activation.
Title: Evaluation of four KCNMA1 channelopathy variants on BK channel current under Ca(V)1.2 activation.
An emerging spectrum of variants and clinical features in KCNMA1-linked channelopathy.
Title: An emerging spectrum of variants and clinical features in KCNMA1-linked channelopathy.
Structural mapping of patient-associated KCNMA1 gene variants.
Title: Structural mapping of patient-associated KCNMA1 gene variants.
Transmembrane determinants of voltage-gating differences between BK (Slo1) and Slo3 channels.
Title: Transmembrane determinants of voltage-gating differences between BK (Slo1) and Slo3 channels.
Down-Regulation of CYP3A4 by the KCa1.1 Inhibition Is Responsible for Overcoming Resistance to Doxorubicin in Cancer Spheroid Models.
Title: Down-Regulation of CYP3A4 by the K(Ca)1.1 Inhibition Is Responsible for Overcoming Resistance to Doxorubicin in Cancer Spheroid Models.
Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models.
Title: Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models.
[Peripheral blood KCNMA1 methylation level is associated with the occurrence and progression of lung cancer].
Title: [Peripheral blood KCNMA1 methylation level is associated with the occurrence and progression of lung cancer].
Identification and functional analysis of two new de novo KCNMA1 variants associated with Liang-Wang syndrome.
Title: Identification and functional analysis of two new de novo KCNMA1 variants associated with Liang-Wang syndrome.
Two novel presentations of KCNMA1-related pathology--Expanding the clinical phenotype of a rare channelopathy.
Title: Two novel presentations of KCNMA1-related pathology--Expanding the clinical phenotype of a rare channelopathy.
The Changes of Gene Expression and Protein Level of Stretch-Activated Chloride Channel in Atrial Myocardium of Dogs with Atrial Fibrillation.
Title: The Changes of Gene Expression and Protein Level of Stretch-Activated Chloride Channel in Atrial Myocardium of Dogs with Atrial Fibrillation.

Submit: New GeneRIF Correction See all GeneRIFs (170)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Cerebellar atrophy, developmental delay, and seizures MedGen: C4539985 OMIM: 617643 GeneReviews: Not available	Compare labs
Epilepsy, idiopathic generalized, susceptibility to, 16 MedGen: C5231421 OMIM: 618596 GeneReviews: Not available	Compare labs
Generalized epilepsy-paroxysmal dyskinesia syndrome MedGen: C5574945 OMIM: 609446 GeneReviews: Not available	Compare labs
Liang-Wang syndrome MedGen: C5231479 OMIM: 618729 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. EBI GWAS Catalog EBI GWAS CatalogPubMed
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome wide association study identifies KCNMA1 contributing to human obesity. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analyses identify variants in developmental genes associated with hypospadias. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH122872 (e-PCR)
- UniSTS:135169

D10S605 (e-PCR)
- UniSTS:46604

WI-15110 (e-PCR)
- UniSTS:65552

STS-U13913 (e-PCR)
- UniSTS:21528

RH102206 (e-PCR)
- UniSTS:96540

RH11276 (e-PCR)
- UniSTS:54574

SHGC-142644 (e-PCR)
- UniSTS:171568

NIB1917 (e-PCR)
- UniSTS:68406

SHGC-105266 (e-PCR)
- UniSTS:169275

D10S307 (e-PCR)
- UniSTS:148028

RH92037 (e-PCR)
- UniSTS:88380

RH45858 (e-PCR)
- UniSTS:15168

G17472 (e-PCR)
- UniSTS:16193

GDB:438010 (e-PCR)
- UniSTS:157264

SHGC-80677 (e-PCR)
- UniSTS:102229

G10716 (e-PCR)
- UniSTS:70746

D10S605 (e-PCR)
- UniSTS:53599

D10S2255 (e-PCR)
- UniSTS:6753

SHGC-144741 (e-PCR)
- UniSTS:172386

G17456 (e-PCR)
- UniSTS:5987

RH41997 (e-PCR)
- UniSTS:5251

SHGC-149064 (e-PCR)
- UniSTS:176777

D10S1730 (e-PCR)
- UniSTS:57995

SHGC-132094 (e-PCR)
- UniSTS:170641

G09279 (e-PCR)
- UniSTS:36501

SHGC-53476 (e-PCR)
- UniSTS:79256

WI-13549 (e-PCR)
- UniSTS:5289

SHGC-132853 (e-PCR)
- UniSTS:170925

SHGC-132140 (e-PCR)
- UniSTS:170671

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516541

D10S109 (e-PCR), detects polymorphism
- UniSTS:146878

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516543

D10S2291 (e-PCR)
- UniSTS:23489

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516545

D10S2378 (e-PCR)
- UniSTS:20676

WI-18797 (e-PCR)
- UniSTS:36809

U09383 (e-PCR)
- UniSTS:125659

D10S2223 (e-PCR)
- UniSTS:78557

SHGC-78665 (e-PCR)
- UniSTS:102114

KCNMA1 (e-PCR)
- UniSTS:503023

SHGC-144912 (e-PCR)
- UniSTS:174320

A003B45 (e-PCR)
- UniSTS:61178

SHGC-105839 (e-PCR)
- UniSTS:169467

D10S2368 (e-PCR)
- UniSTS:75517

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables large conductance calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables large conductance calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables large conductance calcium-activated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular potassium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in micturition	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell volume	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to carbon monoxide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to carbon monoxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed
involved_in smooth muscle contraction involved in micturition	IDA Inferred from Direct Assay more info	PubMed
involved_in vasodilation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel subunit alpha-1

Names: BK channel alpha subunit; BKCA alpha subunit; big potassium channel alpha subunit; calcium-activated potassium channel, subfamily M subunit alpha-1; k(VCA)alpha; maxi-K channel HSLO; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; slo homolog; slowpoke homolog; stretch-activated Kca channel

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012270.1 RefSeqGene

Range

5012..757938

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001014797.3 → NP_001014797.1 Calcium-activated potassium channel subunit alpha-1 isoform a

See identical proteins and their annotated locations for NP_001014797.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AB209488, AC011439, BC024965, U09384

UniProtKB/TrEMBL

A0A1W2PNH9

Related

ENSP00000473714.2, ENST00000604624.6

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001161352.2 → NP_001154824.1 Calcium-activated potassium channel subunit alpha-1 isoform c

See identical proteins and their annotated locations for NP_001154824.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (c) contains a distinct C-terminus, compared to isoform a.

Source sequence(s)

AB113382, AC011439, BC024965, BQ574058, U11058

Consensus CDS

CCDS60569.1

UniProtKB/Swiss-Prot

F8WA96, Q12791, Q12886, Q12917, Q12921, Q12960, Q13150, Q5JQ23, Q5SQR9, Q96LG8, Q9UBB0, Q9UCX0, Q9UQK6

UniProtKB/TrEMBL

A0A1W2PQU4

Related

ENSP00000286628.8, ENST00000286628.14

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001161353.2 → NP_001154825.1 Calcium-activated potassium channel subunit alpha-1 isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (d) contains a distinct C-terminus, compared to isoform a.

Source sequence(s)

AB113575, AC011439, BC024965, BQ574058, U11058

Consensus CDS

CCDS53545.1

UniProtKB/TrEMBL

A0A1W2PQU4

Related

ENSP00000485867.1, ENST00000626620.3

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001271518.2 → NP_001258447.1 Calcium-activated potassium channel subunit alpha-1 isoform e

See identical proteins and their annotated locations for NP_001258447.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) omits an in-frame coding exon. The resulting isoform (e) is shorter compared to isoform a.

Source sequence(s)

AB209488, AB524033, AC011439, BC024965, BC137115

Consensus CDS

CCDS86106.1

UniProtKB/TrEMBL

A0A1W2PNH9, D5MRH1

Related

ENSP00000491555.1, ENST00000640807.1

Conserved Domains (4) summary

pfam00520
Location:156 → 342

Ion_trans; Ion transport protein

pfam03493
Location:491 → 579

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:252 → 337

Ion_trans_2; Ion channel

cl21454
Location:356 → 469

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001271519.2 → NP_001258448.1 Calcium-activated potassium channel subunit alpha-1 isoform f

See identical proteins and their annotated locations for NP_001258448.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (f) contains a distinct C-terminus, compared to isoform a.

Source sequence(s)

AC011439, AC021032, AK024857, BC024965, BC144496

Consensus CDS

CCDS86116.1

UniProtKB/TrEMBL

A0A1W2PQU4, B7ZMF5

Related

ENSP00000491732.1, ENST00000639406.1

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001271520.2 → NP_001258449.1 Calcium-activated potassium channel subunit alpha-1 isoform short1

Status: REVIEWED

Description

Transcript Variant: This variant (7) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short1) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.

Source sequence(s)

AL731556, BC009695, BC024965

Consensus CDS

CCDS73156.1

UniProtKB/TrEMBL

A0A087WZL8, Q6AI34

Related

ENSP00000482747.1, ENST00000618048.2
NM_001271521.2 → NP_001258450.1 Calcium-activated potassium channel subunit alpha-1 isoform short2

Status: REVIEWED

Description

Transcript Variant: This variant (8) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short2) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.

Source sequence(s)

BC009695, BC024965

Consensus CDS

CCDS60572.1

UniProtKB/TrEMBL

S4R453

Related

ENSP00000475086.1, ENST00000481070.1
NM_001271522.2 → NP_001258451.1 Calcium-activated potassium channel subunit alpha-1 isoform short3

See identical proteins and their annotated locations for NP_001258451.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short3) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.

Source sequence(s)

AL731556, BC024965

Consensus CDS

CCDS60571.1

UniProtKB/Swiss-Prot

Q12791

Related

ENSP00000474686.1, ENST00000480683.2
NM_001322829.2 → NP_001309758.1 Calcium-activated potassium channel subunit alpha-1 isoform g

Status: REVIEWED

Source sequence(s)

AC011439, AC021032, AL157833, AL627447, AL731556, AL731560

UniProtKB/TrEMBL

H0Y382

Related

ENSP00000490978.1, ENST00000638991.1
NM_001322830.2 → NP_001309759.1 Calcium-activated potassium channel subunit alpha-1 isoform h

Status: REVIEWED

Source sequence(s)

AC011439, AC021032, AL157833, AL627447, AL731556, AL731560

Consensus CDS

CCDS86121.1

UniProtKB/TrEMBL

A0A1W2PR56, A0A1W2PRG5

Related

ENSP00000492492.1, ENST00000638223.1
NM_001322832.2 → NP_001309761.1 Calcium-activated potassium channel subunit alpha-1 isoform i

Status: REVIEWED

Source sequence(s)

AC011439, AC021032, AL157833, AL627447, AL731556, AL731560

Consensus CDS

CCDS81481.1

UniProtKB/TrEMBL

A0A1W2PQK5, H0Y382

Related

ENSP00000492005.1, ENST00000639486.1

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001322835.2 → NP_001309764.1 Calcium-activated potassium channel subunit alpha-1 isoform j

Status: REVIEWED

Source sequence(s)

AC011439, AC021032, AL157833, AL627447, AL731556, AL731560

UniProtKB/TrEMBL

H0Y382

Related

ENSP00000361498.6, ENST00000372421.10

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001322836.2 → NP_001309765.1 Calcium-activated potassium channel subunit alpha-1 isoform k

Status: REVIEWED

Source sequence(s)

AC011439, AC021032, AL157833, AL627447, AL731556, AL731560

Consensus CDS

CCDS86115.1

UniProtKB/TrEMBL

A0A1W2PP94, A0A1W2PQU4

Related

ENSP00000491418.1, ENST00000640141.1
NM_001322837.2 → NP_001309766.1 Calcium-activated potassium channel subunit alpha-1 isoform l

Status: REVIEWED

Source sequence(s)

AC011439, AC021032, AL157833, AL627447, AL731556, AL731560

UniProtKB/TrEMBL

A0A1W2PQU4

Related

ENSP00000491166.1, ENST00000638754.1
NM_001322838.2 → NP_001309767.1 Calcium-activated potassium channel subunit alpha-1 isoform m

Status: REVIEWED

Source sequence(s)

AC011439, AK310379, AL731575

UniProtKB/TrEMBL

A0A0A0MRC3

Conserved Domains (4) summary

pfam00520
Location:30 → 216

Ion_trans; Ion transport protein

pfam03493
Location:365 → 453

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:126 → 211

Ion_trans_2; Ion channel

cl21454
Location:230 → 343

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001322839.2 → NP_001309768.1 Calcium-activated potassium channel subunit alpha-1 isoform short4

Status: REVIEWED

Source sequence(s)

AL731556
NM_001410940.1 → NP_001397869.1 Calcium-activated potassium channel subunit alpha-1 isoform n

Status: REVIEWED

Source sequence(s)

AC011439, AC021032, AL157833, AL627447, AL731556, AL731560

Consensus CDS

CCDS91276.1

UniProtKB/TrEMBL

A0A1W2PSD3

Related

ENSP00000492806.1, ENST00000639601.1
NM_002247.4 → NP_002238.2 Calcium-activated potassium channel subunit alpha-1 isoform b

See identical proteins and their annotated locations for NP_002238.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (b) contains a distinct C-terminus, compared to isoform a.

Source sequence(s)

AC011439, BC024965, BC137115, BQ574058, U11058, U13913

Consensus CDS

CCDS7352.1

UniProtKB/TrEMBL

A0A1W2PQU4

Related

ENSP00000286627.5, ENST00000286627.10

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

76869602..77637808 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017016222.3 → XP_016871711.2 calcium-activated potassium channel subunit alpha-1 isoform X41

UniProtKB/TrEMBL

A0A1W2PNQ3, H0Y382

Related

ENSP00000491008.1, ENST00000638306.1

Conserved Domains (3) summary

pfam00520
Location:179 → 387

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_024447990.2 → XP_024303758.1 calcium-activated potassium channel subunit alpha-1 isoform X40

UniProtKB/TrEMBL

A0A1W2PNW6, A0A1W2PNY9

Related

ENSP00000491123.1, ENST00000638203.1

Conserved Domains (3) summary

pfam00520
Location:179 → 387

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_024447989.2 → XP_024303757.1 calcium-activated potassium channel subunit alpha-1 isoform X39

UniProtKB/TrEMBL

A0A1W2PNY9, A0A1W2PQA0

Related

ENSP00000491981.1, ENST00000638606.1

Conserved Domains (3) summary

pfam00520
Location:179 → 387

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_005269787.5 → XP_005269844.1 calcium-activated potassium channel subunit alpha-1 isoform X36

UniProtKB/TrEMBL

A0A0A0MRR0, A0A1W2PPY5

Related

ENSP00000491673.1, ENST00000639090.1

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_005269776.5 → XP_005269833.1 calcium-activated potassium channel subunit alpha-1 isoform X34

UniProtKB/TrEMBL

A0A0A0MRR0

Related

ENSP00000361480.4, ENST00000372403.9

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_047425199.1 → XP_047281155.1 calcium-activated potassium channel subunit alpha-1 isoform X26
XM_005269792.3 → XP_005269849.1 calcium-activated potassium channel subunit alpha-1 isoform X25

UniProtKB/TrEMBL

A0A1W2PNH9

Related

ENSP00000385806.3, ENST00000404857.6

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_024447984.2 → XP_024303752.1 calcium-activated potassium channel subunit alpha-1 isoform X18

UniProtKB/TrEMBL

H0Y382, Q5SVJ9

Related

ENSP00000396608.2, ENST00000457953.6

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_005269781.3 → XP_005269838.1 calcium-activated potassium channel subunit alpha-1 isoform X17

UniProtKB/TrEMBL

A0A1W2PNH9, A0A1W2PR62

Related

ENSP00000492075.1, ENST00000639544.1

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_024447987.2 → XP_024303755.1 calcium-activated potassium channel subunit alpha-1 isoform X35

UniProtKB/TrEMBL

A0A1W2PRV4, Q5SVJ8

Related

ENSP00000385717.3, ENST00000404771.8

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_011539785.3 → XP_011538087.1 calcium-activated potassium channel subunit alpha-1 isoform X37

UniProtKB/TrEMBL

H0Y382

Related

ENSP00000492718.1, ENST00000639205.1

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_024447985.2 → XP_024303753.1 calcium-activated potassium channel subunit alpha-1 isoform X28

UniProtKB/TrEMBL

A0A1W2PQ61, H0Y382

Related

ENSP00000491927.1, ENST00000639489.1

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_024447988.2 → XP_024303756.1 calcium-activated potassium channel subunit alpha-1 isoform X38

UniProtKB/TrEMBL

A0A1W2PPZ1, A0A1W2PRB0

Related

ENSP00000492510.1, ENST00000640182.1

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_005269789.3 → XP_005269846.1 calcium-activated potassium channel subunit alpha-1 isoform X24

UniProtKB/TrEMBL

A0A1W2PRG5, Q5SVJ7

Related

ENSP00000361520.2, ENST00000372443.6

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_005269778.3 → XP_005269835.1 calcium-activated potassium channel subunit alpha-1 isoform X16

UniProtKB/TrEMBL

A0A1W2PRN5, H0Y382

Related

ENSP00000492414.1, ENST00000638848.1

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_011539780.3 → XP_011538082.1 calcium-activated potassium channel subunit alpha-1 isoform X15

UniProtKB/TrEMBL

A0A1W2PNH9

Related

ENSP00000491539.1, ENST00000640934.1

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017016217.2 → XP_016871706.1 calcium-activated potassium channel subunit alpha-1 isoform X22

UniProtKB/TrEMBL

A0A1W2PQ93
XM_017016213.3 → XP_016871702.1 calcium-activated potassium channel subunit alpha-1 isoform X13

UniProtKB/TrEMBL

A0A1W2PQ93
XM_047425196.1 → XP_047281152.1 calcium-activated potassium channel subunit alpha-1 isoform X12
XM_011539775.3 → XP_011538077.1 calcium-activated potassium channel subunit alpha-1 isoform X7

UniProtKB/TrEMBL

A0A1W2PNH9

Conserved Domains (4) summary

pfam00520
Location:254 → 440

Ion_trans; Ion transport protein

pfam03493
Location:589 → 677

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:350 → 435

Ion_trans_2; Ion channel

cl21454
Location:454 → 567

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_011539781.4 → XP_011538083.1 calcium-activated potassium channel subunit alpha-1 isoform X20

UniProtKB/TrEMBL

A0A1W2PNH9

Conserved Domains (4) summary

pfam00520
Location:254 → 440

Ion_trans; Ion transport protein

pfam03493
Location:589 → 677

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:350 → 435

Ion_trans_2; Ion channel

cl21454
Location:454 → 567

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017016211.3 → XP_016871700.1 calcium-activated potassium channel subunit alpha-1 isoform X10

UniProtKB/TrEMBL

A0A1W2PQ93
XM_017016210.3 → XP_016871699.1 calcium-activated potassium channel subunit alpha-1 isoform X5

UniProtKB/TrEMBL

A0A1W2PQ93
XM_011539773.3 → XP_011538075.1 calcium-activated potassium channel subunit alpha-1 isoform X4

UniProtKB/TrEMBL

A0A1W2PNH9

Conserved Domains (4) summary

pfam00520
Location:254 → 440

Ion_trans; Ion transport protein

pfam03493
Location:589 → 677

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:350 → 435

Ion_trans_2; Ion channel

cl21454
Location:454 → 567

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017016208.3 → XP_016871697.1 calcium-activated potassium channel subunit alpha-1 isoform X2

UniProtKB/TrEMBL

H0Y382
XM_017016207.3 → XP_016871696.1 calcium-activated potassium channel subunit alpha-1 isoform X1

UniProtKB/TrEMBL

A0A1W2PRG5
XM_017016223.1 → XP_016871712.1 calcium-activated potassium channel subunit alpha-1 isoform X42

UniProtKB/TrEMBL

A0A0A0MRC3

Conserved Domains (4) summary

pfam00520
Location:30 → 216

Ion_trans; Ion transport protein

pfam03493
Location:365 → 453

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:126 → 211

Ion_trans_2; Ion channel

cl21454
Location:230 → 343

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006717826.3 → XP_006717889.1 calcium-activated potassium channel subunit alpha-1 isoform X27

UniProtKB/TrEMBL

A0A1W2PQU4

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_047425197.1 → XP_047281153.1 calcium-activated potassium channel subunit alpha-1 isoform X19

Related

ENSP00000491300.1, ENST00000638283.1
XM_011539778.3 → XP_011538080.1 calcium-activated potassium channel subunit alpha-1 isoform X9

UniProtKB/TrEMBL

A0A1W2PQU4

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_011539783.3 → XP_011538085.1 calcium-activated potassium channel subunit alpha-1 isoform X23

UniProtKB/TrEMBL

A0A1W2PQU4

Related

ENSP00000490982.1, ENST00000639823.1

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_011539777.3 → XP_011538079.1 calcium-activated potassium channel subunit alpha-1 isoform X8

UniProtKB/TrEMBL

A0A1W2PQU4

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_011539782.3 → XP_011538084.1 calcium-activated potassium channel subunit alpha-1 isoform X21

UniProtKB/TrEMBL

A0A1W2PQU4

Related

ENSP00000491840.1, ENST00000638514.1

Conserved Domains (4) summary

pfam00520
Location:254 → 440

Ion_trans; Ion transport protein

pfam03493
Location:589 → 677

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:350 → 435

Ion_trans_2; Ion channel

cl21454
Location:454 → 567

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017016214.3 → XP_016871703.1 calcium-activated potassium channel subunit alpha-1 isoform X14

UniProtKB/TrEMBL

A0A1W2PQU4
XM_017016209.3 → XP_016871698.1 calcium-activated potassium channel subunit alpha-1 isoform X3

UniProtKB/TrEMBL

A0A1W2PQU4
XM_047425195.1 → XP_047281151.1 calcium-activated potassium channel subunit alpha-1 isoform X11
XM_011539774.3 → XP_011538076.1 calcium-activated potassium channel subunit alpha-1 isoform X6

UniProtKB/TrEMBL

A0A1W2PQU4

Conserved Domains (4) summary

pfam00520
Location:254 → 440

Ion_trans; Ion transport protein

pfam03493
Location:589 → 677

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:350 → 435

Ion_trans_2; Ion channel

cl21454
Location:454 → 567

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_024447986.2 → XP_024303754.1 calcium-activated potassium channel subunit alpha-1 isoform X29

UniProtKB/TrEMBL

J3KQ16

Conserved Domains (3) summary

pfam00520
Location:21 → 238

Ion_trans; Ion transport protein

pfam03493
Location:387 → 475

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:252 → 365

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_047425200.1 → XP_047281156.1 calcium-activated potassium channel subunit alpha-1 isoform X30

Related

ENSP00000346321.6, ENST00000354353.9
XM_017016219.3 → XP_016871708.1 calcium-activated potassium channel subunit alpha-1 isoform X31
XM_047425201.1 → XP_047281157.1 calcium-activated potassium channel subunit alpha-1 isoform X33

Related

ENSP00000492236.1, ENST00000639120.1
XM_011539784.3 → XP_011538086.1 calcium-activated potassium channel subunit alpha-1 isoform X32

Conserved Domains (4) summary

pfam00520
Location:254 → 440

Ion_trans; Ion transport protein

pfam03493
Location:589 → 677

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:350 → 435

Ion_trans_2; Ion channel

cl21454
Location:454 → 567

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

XR_007061964.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

77738326..78506527 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054365843.1 → XP_054221818.1 calcium-activated potassium channel subunit alpha-1 isoform X41

UniProtKB/TrEMBL

A0A1W2PNQ3
XM_054365842.1 → XP_054221817.1 calcium-activated potassium channel subunit alpha-1 isoform X40

UniProtKB/TrEMBL

A0A1W2PNW6
XM_054365841.1 → XP_054221816.1 calcium-activated potassium channel subunit alpha-1 isoform X39

UniProtKB/TrEMBL

A0A1W2PQA0
XM_054365838.1 → XP_054221813.1 calcium-activated potassium channel subunit alpha-1 isoform X36

UniProtKB/TrEMBL

A0A1W2PPY5
XM_054365836.1 → XP_054221811.1 calcium-activated potassium channel subunit alpha-1 isoform X34
XM_054365828.1 → XP_054221803.1 calcium-activated potassium channel subunit alpha-1 isoform X26
XM_054365827.1 → XP_054221802.1 calcium-activated potassium channel subunit alpha-1 isoform X25
XM_054365820.1 → XP_054221795.1 calcium-activated potassium channel subunit alpha-1 isoform X18

UniProtKB/TrEMBL

Q5SVJ9
XM_054365819.1 → XP_054221794.1 calcium-activated potassium channel subunit alpha-1 isoform X17

UniProtKB/TrEMBL

A0A1W2PR62
XM_054365837.1 → XP_054221812.1 calcium-activated potassium channel subunit alpha-1 isoform X35

UniProtKB/TrEMBL

Q5SVJ8
XM_054365839.1 → XP_054221814.1 calcium-activated potassium channel subunit alpha-1 isoform X37
XM_054365830.1 → XP_054221805.1 calcium-activated potassium channel subunit alpha-1 isoform X28

UniProtKB/TrEMBL

A0A1W2PQ61
XM_054365840.1 → XP_054221815.1 calcium-activated potassium channel subunit alpha-1 isoform X38

UniProtKB/TrEMBL

A0A1W2PRB0
XM_054365826.1 → XP_054221801.1 calcium-activated potassium channel subunit alpha-1 isoform X24

UniProtKB/TrEMBL

Q5SVJ7
XM_054365818.1 → XP_054221793.1 calcium-activated potassium channel subunit alpha-1 isoform X16

UniProtKB/TrEMBL

A0A1W2PRN5
XM_054365817.1 → XP_054221792.1 calcium-activated potassium channel subunit alpha-1 isoform X15
XM_054365824.1 → XP_054221799.1 calcium-activated potassium channel subunit alpha-1 isoform X22
XM_054365815.1 → XP_054221790.1 calcium-activated potassium channel subunit alpha-1 isoform X13
XM_054365814.1 → XP_054221789.1 calcium-activated potassium channel subunit alpha-1 isoform X12
XM_054365809.1 → XP_054221784.1 calcium-activated potassium channel subunit alpha-1 isoform X7
XM_054365822.1 → XP_054221797.1 calcium-activated potassium channel subunit alpha-1 isoform X20
XM_054365812.1 → XP_054221787.1 calcium-activated potassium channel subunit alpha-1 isoform X10
XM_054365807.1 → XP_054221782.1 calcium-activated potassium channel subunit alpha-1 isoform X5
XM_054365806.1 → XP_054221781.1 calcium-activated potassium channel subunit alpha-1 isoform X4
XM_054365804.1 → XP_054221779.1 calcium-activated potassium channel subunit alpha-1 isoform X2
XM_054365803.1 → XP_054221778.1 calcium-activated potassium channel subunit alpha-1 isoform X1
XM_054365844.1 → XP_054221819.1 calcium-activated potassium channel subunit alpha-1 isoform X42
XM_054365829.1 → XP_054221804.1 calcium-activated potassium channel subunit alpha-1 isoform X27
XM_054365821.1 → XP_054221796.1 calcium-activated potassium channel subunit alpha-1 isoform X19
XM_054365811.1 → XP_054221786.1 calcium-activated potassium channel subunit alpha-1 isoform X9
XM_054365825.1 → XP_054221800.1 calcium-activated potassium channel subunit alpha-1 isoform X23
XM_054365810.1 → XP_054221785.1 calcium-activated potassium channel subunit alpha-1 isoform X8
XM_054365823.1 → XP_054221798.1 calcium-activated potassium channel subunit alpha-1 isoform X21
XM_054365816.1 → XP_054221791.1 calcium-activated potassium channel subunit alpha-1 isoform X14
XM_054365805.1 → XP_054221780.1 calcium-activated potassium channel subunit alpha-1 isoform X3
XM_054365813.1 → XP_054221788.1 calcium-activated potassium channel subunit alpha-1 isoform X11
XM_054365808.1 → XP_054221783.1 calcium-activated potassium channel subunit alpha-1 isoform X6
XM_054365832.1 → XP_054221807.1 calcium-activated potassium channel subunit alpha-1 isoform X29
XM_054365831.1 → XP_054221806.1 calcium-activated potassium channel subunit alpha-1 isoform X30
XM_054365833.1 → XP_054221808.1 calcium-activated potassium channel subunit alpha-1 isoform X31
XM_054365835.1 → XP_054221810.1 calcium-activated potassium channel subunit alpha-1 isoform X33
XM_054365834.1 → XP_054221809.1 calcium-activated potassium channel subunit alpha-1 isoform X32