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Snap29 Synaptosomal-associated protein 29kDa [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37774, updated on 9-Dec-2024

Summary

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Official Symbol
Snap29provided by FlyBase
Official Full Name
Synaptosomal-associated protein 29kDaprovided by FlyBase
Primary source
FLYBASE:FBgn0034913
Locus tag
Dmel_CG11173
See related
AllianceGenome:FB:FBgn0034913
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11173; Dmel\CG11173; dSNAP-29; MENE (2R)-E; MENE(2R)-E; SNAP-29; snap29; SNAP29; ubisnap; Ubisnap; usnp; Usnp
Summary
Enables SNAP receptor activity and SNARE binding activity. Involved in several processes, including T-tubule organization; autophagosome maturation; and secretory granule-lysosome fusion. Part of SNARE complex. Is expressed in several structures, including adult head; embryonic/larval garland cell; garland cell primordium; and imaginal disc. Used to study CEDNIK syndrome. Human ortholog(s) of this gene implicated in CEDNIK syndrome. Orthologous to human SNAP29 (synaptosome associated protein 29). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Snap29 in Genome Data Viewer
Location:
60A3-60A3; 2-105 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23843483..23844763, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19731006..19732286, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44805 Neighboring gene uncharacterized protein Neighboring gene shutdown Neighboring gene uncharacterized protein Neighboring gene yantar Neighboring gene eukaryotic translation initiation factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionarily conserved role and physiological relevance of a STX17/Syx17 (syntaxin 17)-containing SNARE complex in autophagosome fusion with endosomes and lysosomes. Hegedűs K, et al. Autophagy, 2013 Oct. PMID 24113031
  2. The Ykt6-Snap29-Syx13 SNARE complex promotes crinophagy via secretory granule fusion with Lamp1 carrier vesicles. Szenci G, et al. Sci Rep, 2024 Feb 8. PMID 38331993, Free PMC Article
  3. The multi-functional SNARE protein Ykt6 in autophagosomal fusion processes. Kriegenburg F, et al. Cell Cycle, 2019 Mar-Apr. PMID 30836834, Free PMC Article
  4. SNAP-24, a Drosophila SNAP-25 homologue on granule membranes, is a putative mediator of secretion and granule-granule fusion in salivary glands. Niemeyer BA, et al. J Cell Sci, 2000 Nov. PMID 11058092
  5. STING controls energy stress-induced autophagy and energy metabolism via STX17. Rong Y, et al. J Cell Biol, 2022 Jul 4. PMID 35510944, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, we identify a novel role for Snap29, an unconventional SNARE, in promoting kinetochore assembly during mitosis in Drosophila and human cells. Snap29 localizes to the outer kinetochore and prevents chromosome mis-segregation and the formation of cells with fragmented nuclei.
    Title: An essential step of kinetochore formation controlled by the SNARE protein Snap29.
  2. SNAP-29 mediates an essential process in Drosophila development
    Title: Drosophila SNAP-29 is an essential SNARE that binds multiple proteins involved in membrane traffic.
  3. support a role of Snap29 at key steps of membrane trafficking, and predict that signaling defects may contribute to the pathogenesis of cerebral dysgenesis
    Title: Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila.
  4. Syntaxin17 is recruited to the outer membrane of autophagosomes to mediate fusion through its interactions with ubisnap (SNAP-29) and VAMP7 in Drosophila melanogaster
    Title: Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SNAP receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables SNARE binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in T-tubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of secretion by cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in secretory granule-lysosome fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SNARE complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Synaptosomal-associated protein 29kDa
Names
CG11173-PA
Snap29-PA
ubisnap

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23843483..23844763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079107.4 → NP_523831.1  Synaptosomal-associated protein 29kDa [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523831.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1I8
    Related
    FBpp0072145
    Conserved Domains (2) summary
    cd15856
    Location:222 → 280
    SNARE_SNAP29C; C-terminal SNARE motif of SNAP29
    cd15887
    Location:72 → 136
    SNARE_SNAP29N; N-terminal SNARE motif of SNAP29
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1I8 Q9W1I8

Gene LinkOut

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