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sona sol narae [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37762, updated on 9-Dec-2024

Summary

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Official Symbol
sonaprovided by FlyBase
Official Full Name
sol naraeprovided by FlyBase
Primary source
FLYBASE:FBgn0034903
Locus tag
Dmel_CG9850
See related
AllianceGenome:FB:FBgn0034903
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11169; CG9850; dimp; Dimp; Dmel\CG9850; Sona
Summary
Enables metalloendopeptidase activity. Involved in imaginal disc-derived appendage development; positive regulation of cell communication; and proteolysis. Located in Golgi-associated vesicle; endosome; and extracellular exosome. Is expressed in several structures, including imaginal disc; ommatidium; presumptive femur; presumptive tibia; and presumptive unguis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See sona in Genome Data Viewer
Location:
59F7-60A1; 2-104 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23753477..23798395, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19641000..19685918, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An ADAMTS Sol narae is required for cell survival in Drosophila. Tsogtbaatar O, et al. Sci Rep, 2019 Feb 4. PMID 30718556, Free PMC Article
  2. Wg secreted by conventional Golgi transport diffuses and forms Wg gradient whereas Wg tethered to extracellular vesicles do not diffuse. Won JH, et al. Cell Death Differ, 2021 Mar. PMID 33028960, Free PMC Article
  3. Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster. Cho DG, et al. Mol Cells, 2021 Jan 31. PMID 33510049, Free PMC Article
  4. Exosomal arrow (Arr)/lipoprotein receptor protein 6 (LRP6) in Drosophila melanogaster increases the extracellular level of Sol narae (Sona) in a Wnt-independent manner. Han JH, et al. Cell Death Dis, 2020 Nov 3. PMID 33139721, Free PMC Article
  5. POU domain motif3 (Pdm3) induces wingless (wg) transcription and is essential for development of larval neuromuscular junctions in Drosophila. Kim Y, et al. Sci Rep, 2020 Jan 16. PMID 31949274, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster.
    Title: Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster.
  2. An ADAMTS Sol narae is required for cell survival in Drosophila.
    Title: An ADAMTS Sol narae is required for cell survival in Drosophila.
  3. Sona generates Wg C-terminal domain that carries out subsets of Wg signaling.
    Title: ADAMTS Sol narae cleaves extracellular Wingless to generate a novel active form that regulates cell proliferation in Drosophila.
  4. This study suggests that Sona is involved in Wg signaling by regulating the level of extracellular Wg.
    Title: Sol narae (Sona) is a Drosophila ADAMTS involved in Wg signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in imaginal disc-derived appendage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Wnt protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi-associated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sol narae
Names
CG9850-PA
CG9850-PC
CG9850-PD
CG9850-PE
CG9850-PF
Dlg-interacting metalloprotease
sona-PA
sona-PC
sona-PD
sona-PE
sona-PF
NP_001027572.2
NP_001137746.1
NP_001261157.1
NP_001261158.1
NP_611827.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23753477..23798395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144274.3 → NP_001137746.1  sol narae, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137746.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZP6
    Conserved Domains (1) summary
    cd04272
    Location:313 → 542
    ZnMc_salivary_gland_MPs; Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.

  2. NM_137983.5 → NP_611827.2  sol narae, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611827.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1J9
    Conserved Domains (1) summary
    cd04272
    Location:313 → 542
    ZnMc_salivary_gland_MPs; Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.

  3. NM_001274229.2 → NP_001261158.1  sol narae, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261158.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGD6
    Conserved Domains (1) summary
    cd04272
    Location:313 → 541
    ZnMc_salivary_gland_MPs; Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.

  4. NM_001032400.3 → NP_001027572.2  sol narae, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027572.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2MGN5
    Conserved Domains (1) summary
    cd04272
    Location:313 → 541
    ZnMc_salivary_gland_MPs; Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.

  5. NM_001274228.2 → NP_001261157.1  sol narae, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261157.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFG8
    Conserved Domains (1) summary
    cd04272
    Location:313 → 541
    ZnMc_salivary_gland_MPs; Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFG8 A0A0B4KFG8
A0A0B4KGD6 A0A0B4KGD6
B7YZP6 B7YZP6
Q2MGN5 Q2MGN5
Q8MT72 Q8MT72
Q9W1J9 Q9W1J9

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