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Kaz1-ORFB Kaz1-ORFB [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3772691, updated on 4-Jan-2025

Summary

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Official Symbol
Kaz1-ORFBprovided by FlyBase
Official Full Name
Kaz1-ORFBprovided by FlyBase
Primary source
FLYBASE:FBgn0063923
Locus tag
Dmel_CG1220
See related
AllianceGenome:FB:FBgn0063923
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1220; CG33045; Dmel\CG1220; Kaz1; ORF B; ORF C; ORF D; ORF E
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Located in extracellular region. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval midgut primordium; gastric caecum; and larval muscle system. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Kaz1-ORFB in Genome Data Viewer
Location:
61B2-61B2; 3-1 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (216625..218058)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (216625..218058)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene thoc7 Neighboring gene Dis3 like 3'-5' exoribonuclease 2 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene pyrexia Neighboring gene long non-coding RNA:CR42862 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Drosophila gene encoding multiple splice variants of Kazal-type serine protease inhibitor-like proteins with potential destinations of mitochondria, cytosol and the secretory pathway. Niimi T, et al. Eur J Biochem, 1999 Nov. PMID 10542076
  2. Identifying new players in structural synaptic plasticity through dArc1 interrogation. Xiao C, et al. iScience, 2023 Nov 17. PMID 37876812, Free PMC Article
  3. Development of fly tolerance to consuming a high-protein diet requires physiological, metabolic and transcriptional changes. Yurkevych IS, et al. Biogerontology, 2020 Oct. PMID 32468146
  4. The tobacco phosphatidylethanolamine-binding protein NtFT4 increases the lifespan of Drosophila melanogaster by interacting with the proteostasis network. Känel P, et al. Aging (Albany NY), 2022 Apr 8. PMID 35396341, Free PMC Article
  5. Notch and Ras signaling pathway effector genes expressed in fusion competent and founder cells during Drosophila myogenesis. Artero R, et al. Development, 2003 Dec. PMID 14602676

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Kaz1-ORFB
Names
CG1220-PA
CG1220-PE
CG1220-PF
CG1220-PH
KAZ1 type C1
KAZ1 type C2
KAZ1 type C3
KAZ1 type D
KAZ1 type E
KAZ1 type beta
Kaz1-ORFB-PA
Kaz1-ORFB-PE
Kaz1-ORFB-PF
Kaz1-ORFB-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    216625..218058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167809.4 → NP_728495.1  Kaz1-ORFB, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728495.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KYD6, Q8IRJ6
    Conserved Domains (1) summary
    cl00097
    Location:69 → 112
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  2. NM_167810.3 → NP_728496.2  Kaz1-ORFB, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728496.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KYD6, Q8IRJ6
    Conserved Domains (1) summary
    cl00097
    Location:69 → 112
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  3. NM_001031920.3 → NP_001027091.1  Kaz1-ORFB, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027091.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O97042, Q7YZA1
    Conserved Domains (1) summary
    cl00097
    Location:69 → 99
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  4. NM_138169.5 → NP_612013.3  Kaz1-ORFB, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612013.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KYD6, Q8IRJ6
    Conserved Domains (1) summary
    cl00097
    Location:69 → 112
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O97042 O97042
Q7KYD6 Q7KYD6
Q7YZA1 Q7YZA1
Q8IRJ6 Q8IRJ6

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