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bbx bobby sox [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3772670, updated on 4-Jan-2025

Summary

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Official Symbol
bbxprovided by FlyBase
Official Full Name
bobby soxprovided by FlyBase
Primary source
FLYBASE:FBgn0024251
Locus tag
Dmel_CG1414
See related
AllianceGenome:FB:FBgn0024251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-19Fb; CG1414; CG32527; Dmel\CG1414; tu2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human BBX (BBX high mobility group box domain containing). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See bbx in Genome Data Viewer
Location:
19F5-19F6; 1-65 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21363028..21373145)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21234055..21244172)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene small optic lobes Neighboring gene Septin 1 Neighboring gene waclaw Neighboring gene antisense RNA:CR45612 Neighboring gene antisense RNA:CR45611 Neighboring gene sluggish A Neighboring gene ncRNA Neighboring gene DEAD-box helicase 56

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The sluggish-A gene of Drosophila melanogaster is expressed in the nervous system and encodes proline oxidase, a mitochondrial enzyme involved in glutamate biosynthesis. Hayward DC, et al. Proc Natl Acad Sci U S A, 1993 Apr 1. PMID 8096642, Free PMC Article
  2. The evolution of High Mobility Group Box (HMGB) chromatin proteins in multicellular animals. Sessa L, et al. Gene, 2007 Jan 31. PMID 17156942
  3. Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of Drosophila. Maleszka R, et al. Proc Natl Acad Sci U S A, 1998 Mar 31. PMID 9520435, Free PMC Article
  4. Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1. Lou WP, et al. Front Mol Neurosci, 2017. PMID 29379413, Free PMC Article
  5. Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling. Bonnay F, et al. EMBO J, 2014 Oct 16. PMID 25180232, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bobby sox
Names
CG1414-PB
CG1414-PC
CG1414-PD
CG1414-PE
bbx-PB
bbx-PC
bbx-PD
bbx-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    21363028..21373145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001031917.2 → NP_001027088.1  bobby sox, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027088.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61348
    Conserved Domains (1) summary
    cd01388
    Location:296 → 367
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

  2. NM_001031916.2 → NP_001027087.1  bobby sox, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027087.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61348
    Conserved Domains (1) summary
    cd01388
    Location:296 → 367
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

  3. NM_001272842.2 → NP_001259771.1  bobby sox, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259771.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61348
    Conserved Domains (1) summary
    cd01388
    Location:296 → 367
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

  4. NM_001272841.2 → NP_001259770.1  bobby sox, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259770.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61348
    Conserved Domains (1) summary
    cd01388
    Location:296 → 367
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O61348 O61348
Q86NW8 Q86NW8

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