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CG13430 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3772580, updated on 9-Dec-2024

Summary

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Official Symbol
CG13430provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034518
Locus tag
Dmel_CG13430
See related
AllianceGenome:FB:FBgn0034518
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33008; Dmel\CG13430; SP70
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36); PRSS53 (serine protease 53); and TMPRSS4 (transmembrane serine protease 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG13430 in Genome Data Viewer
Location:
57A5-57A5; 2-91 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20550334..20552090, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16437839..16439595, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Odorant-binding protein 57e Neighboring gene Cuticular protein 57A Neighboring gene Odorant-binding protein 57d Neighboring gene BLOC-1 related complex subunit 7 Neighboring gene lateral muscles scarcer Neighboring gene Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Neighboring gene antisense RNA:CR44653 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Odorant-binding proteins OBP57d and OBP57e affect taste perception and host-plant preference in Drosophila sechellia. Matsuo T, et al. PLoS Biol, 2007 May. PMID 17456006, Free PMC Article
  2. RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance. Pawar V, et al. J Biomol Screen, 2011 Apr. PMID 21364088, Free PMC Article
  3. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
  4. Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families. Shah PK, et al. Gene, 2008 Jan 15. PMID 17996400
  5. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG13430-PA
CG13430-PB
NP_001027441.1
NP_001027442.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20550334..20552090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032271.2 → NP_001027442.1  uncharacterized protein Dmel_CG13430, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027442.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1E3
    Conserved Domains (2) summary
    smart00020
    Location:31 → 259
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:32 → 262
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001032270.2 → NP_001027441.1  uncharacterized protein Dmel_CG13430, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027441.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1E3
    Conserved Domains (2) summary
    smart00020
    Location:31 → 259
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:32 → 262
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K1E3 Q7K1E3

Gene LinkOut

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