Plp Pericentrin-like protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Plpprovided by FlyBase
Official Full Name: Pericentrin-like proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0086690
Locus tag: Dmel_CG33957
See related: AllianceGenome:FB:FBgn0086690
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AKAP450; CG13459; CG18648; CG33957; CG6735; cp309; Cp309; CP309; d-plp; D-Plp; D-PLP; Dmel\CG33957; dplp; dPLP; Dplp; DPlp; DPLP; l(3)s2172; Pact; PACT; PCNT; plp; PLP; pPlp
Summary: Predicted to enable molecular adaptor activity. Involved in cilium-dependent cell motility; microtubule cytoskeleton organization; and sensory perception of sound. Located in centriole and ciliary basal body. Is expressed in several structures, including adult midgut progenitor cell; chordotonal neurons; epithelial cell; germline cell; and salivary gland imaginal ring. Human ortholog(s) of this gene implicated in microcephalic osteodysplastic primordial dwarfism type II. Orthologous to human PCNT (pericentrin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 71B2-71B4; 3-42 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (15066081..15094724, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (15059181..15087824, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pericentrin interacts with Kinesin-1 to drive centriole motility.
Title: Pericentrin interacts with Kinesin-1 to drive centriole motility.
Data dhow that spindle assembly abnormal 6 protein (SAS-6) is recruited to the centriole through an undescribed pathway mediated by pericentrin.
Title: Pericentrin-mediated SAS-6 recruitment promotes centriole assembly.
The partial loss of these structures may largely explain the complex centriole, centrosome and cilium defects we observe in Plp mutant cells.
Title: Drosophila PLP assembles pericentriolar clouds that promote centriole stability, cohesion and MT nucleation.
Cnn and PLP directly interact at two defined sites to coordinate the cell cycle-dependent rearrangement and scaffolding activity of the centrosome to permit normal centrosome organization, cell division, and embryonic viability.
Title: Interphase centrosome organization by the PLP-Cnn scaffold is required for centrosome function.
Basal body formation in the male testes and the production of functional sperm does not rely on the PLP-CaM interaction, whereas production of functional mechanosensory neurons does.
Title: Drosophila pericentrin requires interaction with calmodulin for its function at centrosomes and neuronal basal bodies but not at sperm basal bodies.
Data indicate that interphase centrioles are closely associated with Sas-4, Spd-2, Polo kinase, Pericentrin-like protein (Dplp), Asterless (Asl), Plk4 kinase, Centrosomin (Cnn) and gamma-tubulin.
Title: Structured illumination of the interface between centriole and peri-centriolar material.
identification of CP309 which can bind to calmodulin; it is is required for microtubule nucleation mediated by centrosomes and it interacts with the gamma-tubulin small complex
Title: Characterization of a Drosophila centrosome protein CP309 that shares homology with Kendrin and CG-NAP.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium-dependent cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Pericentrin-like protein

Names: CG33957-PC; CG33957-PD; CG33957-PF; CG33957-PG; CG33957-PH; CG33957-PJ; CG33957-PK; CG33957-PL; CG33957-PM; CG33957-PN; CG33957-PO; CG33957-PP; Plp-PC; Plp-PD; Plp-PF; Plp-PG; Plp-PH; Plp-PJ; Plp-PK; Plp-PL; Plp-PM; Plp-PN; Plp-PO; Plp-PP; cp309; drosophila pericentrin like protein; lethal (3) s2172; pericentrin; pericentrin-like; pericentrin-like protein; pericentrin-like-protein; pericentrin/AKAP450 centrosomal targeting

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

15066081..15094724 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274935.2 → NP_001261864.1 Pericentrin-like protein, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261864.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCK2, Q6UBD8

Conserved Domains (3) summary

TIGR02168
Location:1464 → 2286

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2403 → 2475

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl23720
Location:1829 → 1936

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001274936.1 → NP_001261865.1 Pericentrin-like protein, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261865.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFA8, Q6UBD8

Conserved Domains (4) summary

TIGR02168
Location:1272 → 2324

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2459 → 2531

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl09111
Location:1272 → 1328

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

cl23720
Location:1885 → 1992

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001274932.1 → NP_001261861.1 Pericentrin-like protein, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261861.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFP0, Q6UBD8

Conserved Domains (3) summary

TIGR02168
Location:1536 → 2358

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2475 → 2547

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl23720
Location:1901 → 2008

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001259833.2 → NP_001246762.2 Pericentrin-like protein, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246762.2

Status: REVIEWED

UniProtKB/TrEMBL

M9ND93, Q6UBD8

Conserved Domains (3) summary

TIGR02168
Location:1344 → 2404

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2539 → 2611

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl23720
Location:1965 → 2072

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001259832.1 → NP_001246761.1 Pericentrin-like protein, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246761.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NFV3, Q6UBD8

Conserved Domains (3) summary

TIGR02168
Location:1637 → 2459

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2576 → 2648

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl23720
Location:2002 → 2109

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001274933.1 → NP_001261862.1 Pericentrin-like protein, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261862.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFJ2, Q6UBD8

Conserved Domains (4) summary

TIGR02168
Location:1445 → 2505

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2640 → 2712

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl09111
Location:1445 → 1501

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

cl23720
Location:2066 → 2173

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001274934.1 → NP_001261863.1 Pericentrin-like protein, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261863.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PI63, Q6UBD8

Conserved Domains (3) summary

TIGR02168
Location:1709 → 2531

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2648 → 2720

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl23720
Location:2074 → 2181

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001032402.2 → NP_001027574.2 Pericentrin-like protein, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027574.2

Status: REVIEWED

UniProtKB/TrEMBL

Q400N2, Q6UBD8

Conserved Domains (4) summary

TIGR02168
Location:1517 → 2569

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2704 → 2776

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl09111
Location:1517 → 1573

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

cl23720
Location:2130 → 2237

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001274930.1 → NP_001261859.1 Pericentrin-like protein, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261859.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCJ5, Q6UBD8

Conserved Domains (4) summary

TIGR02168
Location:1513 → 2565

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2700 → 2772

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl09111
Location:1513 → 1569

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

cl23720
Location:2126 → 2233

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001274937.1 → NP_001261866.1 Pericentrin-like protein, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261866.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFP4

Conserved Domains (3) summary

TIGR02168
Location:571 → 1393

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:1510 → 1582

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl23720
Location:936 → 1043

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001274931.1 → NP_001261860.1 Pericentrin-like protein, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261860.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFA3

Conserved Domains (4) summary

TIGR02168
Location:379 → 1431

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:1566 → 1638

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl09111
Location:379 → 435

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

cl23720
Location:992 → 1099

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001032401.1 → NP_001027573.1 Pericentrin-like protein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027573.1

Status: REVIEWED

UniProtKB/TrEMBL

Q400N1, Q8T9E5

Conserved Domains (2) summary

pfam10495
Location:918 → 990

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl23720
Location:344 → 451

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
M9ND93		M9ND93
M9NFV3		M9NFV3
M9PCJ5		M9PCJ5
M9PCK2		M9PCK2
M9PFA3		M9PFA3
M9PFA8		M9PFA8
M9PFJ2		M9PFJ2
M9PFP0		M9PFP0
M9PFP4		M9PFP4
M9PI63		M9PI63
Q400N1		Q400N1
Q400N2		Q400N2
Q6UBD8		Q6UBD8
Q8T9E5		Q8T9E5