Prx5 Peroxiredoxin 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prx5provided by FlyBase
Official Full Name: Peroxiredoxin 5provided by FlyBase
Primary source: FLYBASE:FBgn0038570
Locus tag: Dmel_CG7217
See related: AllianceGenome:FB:FBgn0038570
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG 32920; CG 7217; CG3292; CG32920; CG7217; Dmel\CG7217; dPRDX5; dprx5; dPrx5; dPrxV; PRDX5; prx5
Summary: Predicted to enable thioredoxin peroxidase activity. Involved in several processes, including cell redox homeostasis; determination of adult lifespan; and hydrogen peroxide catabolic process. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and trunk visceral muscle primordium. Orthologous to human PRDX5 (peroxiredoxin 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 90F4-90F4; 3-62 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18165442..18167273, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (13991164..13992995, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest JNK/FOXO mediated dPrxV (Peroxiredoxin 5) expression plays a critical role in Drosophila melanogaster gut during bacterial infection in protecting the host gut epithelial cells from oxidative damage
Title: JNK/FOXO mediated PeroxiredoxinV expression regulates redox homeostasis during Drosophila melanogaster gut infection.
flies underexpressing peroxiredoxin 3 and peroxiredoxin 5 showed an 80% reduction in lifespan and a massive induction of apoptosis in the muscle and digestive system tissues
Title: Mitochondrial peroxiredoxins are critical for the maintenance of redox state and the survival of adult Drosophila.
Overexpressiion of Prx5 were more susceptible to bacterial infection in Drosophila melanogaster .
Title: Peroxiredoxin 5 modulates immune response in Drosophila.
the antioxidant and anti-apoptotic activities of dPrx5 play a critical role in development and aging of the fly
Title: Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin peroxidase activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin peroxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables thioredoxin-dependent peroxiredoxin activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell redox homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial matrix	TAS Traceable Author Statement more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: peroxiredoxin 5

Names: CG7217-PA; CG7217-PB; Prx5-PA; Prx5-PB; peroxiredoxin V

NP_001027191.1

EC 1.-.-.-

EC 1.11.1.24

NP_650679.3

EC 1.-.-.-

EC 1.11.1.24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

18165442..18167273 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_142422.5 → NP_650679.3 peroxiredoxin 5, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650679.3

Status: REVIEWED

UniProtKB/TrEMBL

Q960M4

Conserved Domains (2) summary

cd03013
Location:37 → 187

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...

pfam00578
Location:37 → 169

AhpC-TSA; AhpC/TSA family
NM_001032020.3 → NP_001027191.1 peroxiredoxin 5, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027191.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960M4

Conserved Domains (2) summary

cd03013
Location:37 → 187

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...

pfam00578
Location:37 → 169

AhpC-TSA; AhpC/TSA family