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His1:CG33828 histone H1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3771910, updated on 9-Dec-2024

Summary

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Official Symbol
His1:CG33828provided by FlyBase
Official Full Name
histone H1provided by FlyBase
Primary source
FLYBASE:FBgn0053828
Locus tag
Dmel_CG33828
See related
AllianceGenome:FB:FBgn0053828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33828; Dmel\CG33828
Summary
Predicted to enable chromatin DNA binding activity. Involved in chromosome organization and heterochromatin formation. Predicted to be located in chromatin. Predicted to be part of nucleosome. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including H1-5 (H1.5 linker histone, cluster member). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See His1:CG33828 in Genome Data Viewer
Location:
39D5-39D5; 2-54 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21476302..21477324)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21476302..21477324)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene histone H4 Neighboring gene histone H3 Neighboring gene histone H2B Neighboring gene histone H2A Neighboring gene small non-coding RNA 430h

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hinfp is a guardian of the somatic genome by repressing transposable elements. Nirala NK, et al. Proc Natl Acad Sci U S A, 2021 Oct 12. PMID 34620709, Free PMC Article
  2. Drosophila melanogaster linker histone dH1 is required for transposon silencing and to preserve genome integrity. Vujatovic O, et al. Nucleic Acids Res, 2012 Jul. PMID 22406835, Free PMC Article
  3. Drosophila ribosomal proteins are associated with linker histone H1 and suppress gene transcription. Ni JQ, et al. Genes Dev, 2006 Jul 15. PMID 16816001, Free PMC Article
  4. The Release 6 reference sequence of the Drosophila melanogaster genome. Hoskins RA, et al. Genome Res, 2015 Mar. PMID 25589440, Free PMC Article
  5. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone H1
Names
CG33828-PA
His1:CG33828-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21476302..21477324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032153.2 → NP_001027324.1  histone H1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027324.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P02255, Q4ABD3
    UniProtKB/TrEMBL
    C4IY08
    Conserved Domains (1) summary
    pfam00538
    Location:46 → 118
    Linker_histone; linker histone H1 and H5 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02255.1 P02255

Gene LinkOut

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Molecular Biology Databases
Research Materials