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Mtmr6 Myotubularin related protein 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37707, updated on 9-Dec-2024

Summary

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Official Symbol
Mtmr6provided by FlyBase
Official Full Name
Myotubularin related protein 6provided by FlyBase
Primary source
FLYBASE:FBgn0028497
Locus tag
Dmel_CG3530
See related
AllianceGenome:FB:FBgn0028497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA; BcDNA:GH04637; CG18093; CG3530; Dmel\CG3530; Dmtm-6; Dmtm6; dMtmr6; MTMR6/7/8
Summary
Predicted to enable phosphatidylinositol-3,5-bisphosphate phosphatase activity and phosphatidylinositol-3-phosphate phosphatase activity. Involved in mitotic cell cycle and regulation of macroautophagy. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human MTMR6 (myotubularin related protein 6); MTMR7 (myotubularin related protein 7); and MTMR8 (myotubularin related protein 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Mtmr6 in Genome Data Viewer
Location:
59D10-59D10; 2-102 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23389009..23396680, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19276532..19284203, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44784 Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 2B subunit delta Neighboring gene reduction of Rh1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myotubularin phosphatases: policing 3-phosphoinositides. Robinson FL, et al. Trends Cell Biol, 2006 Aug. PMID 16828287
  2. Condition-dependent functional shift of two Drosophila Mtmr lipid phosphatases in autophagy control. Manzéger A, et al. Autophagy, 2021 Dec. PMID 33779490, Free PMC Article
  3. PI3P-dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase. Ghosh A, et al. Life Sci Alliance, 2023 Sep. PMID 37316298, Free PMC Article
  4. Comparative transcriptional profiling and evolutionary analysis of the GRAM domain family in eukaryotes. Jiang SY, et al. Dev Biol, 2008 Feb 15. PMID 18201690
  5. MetaBlasts: tracing protein tyrosine phosphatase gene family roots from Man to Drosophila melanogaster and Caenorhabditis elegans genomes. Wälchli S, et al. Gene, 2000 Aug 8. PMID 10940550

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,5-bisphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-3-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine/serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myotubularin related protein 6
Names
CG3530-PA
CG3530-PB
CG3530-PC
MYOTUBULARIN-like
Mtmr6-PA
Mtmr6-PB
Mtmr6-PC
NP_001097433.1
NP_611791.2
NP_726322.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23389009..23396680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137947.3 → NP_611791.2  myotubularin related protein 6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611791.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3A1, Q9W1Q6
    Related
    FBpp0071937
    Conserved Domains (3) summary
    cd13210
    Location:4 → 101
    PH-GRAM_MTMR6-like; Myotubularian (MTM) related (MTMR) 7 and 8 proteins Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15738
    Location:621 → 681
    FYVE_MTMR_unchar; FYVE-related domain found in uncharacterized myotubularin-related proteins mainly from eumetazoa
    pfam06602
    Location:107 → 442
    Myotub-related; Myotubularin-like phosphatase domain

  2. NM_001103963.2 → NP_001097433.1  myotubularin related protein 6, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097433.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KK51
    Conserved Domains (3) summary
    cd15738
    Location:571 → 631
    FYVE_MTMR_unchar; FYVE-related domain found in uncharacterized myotubularin-related proteins mainly from eumetazoa
    pfam06602
    Location:57 → 392
    Myotub-related; Myotubularin-like phosphatase domain
    cl17171
    Location:1 → 51
    PH-like; Pleckstrin homology-like domain

  3. NM_166603.2 → NP_726322.1  myotubularin related protein 6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726322.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MLR7
    Related
    FBpp0071938
    Conserved Domains (3) summary
    cd13210
    Location:78 → 173
    PH-GRAM_MTMR6-like; Myotubularian (MTM) related (MTMR) 7 and 8 proteins Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15738
    Location:693 → 753
    FYVE_MTMR_unchar; FYVE-related domain found in uncharacterized myotubularin-related proteins mainly from eumetazoa
    pfam06602
    Location:179 → 514
    Myotub-related; Myotubularin-like phosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KK51 Q7KK51
Q8MLR7 Q8MLR7
Q9W1Q6 Q9W1Q6

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