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asrij asrij [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37637, updated on 4-Jan-2025

Summary

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Official Symbol
asrijprovided by FlyBase
Official Full Name
asrijprovided by FlyBase
Primary source
FLYBASE:FBgn0034793
Locus tag
Dmel_CG13533
See related
AllianceGenome:FB:FBgn0034793
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
arj; Asrij; CG13533; Dmasrij; Dmel\CG13533; FBgn 34793
Summary
Involved in several processes, including hematopoietic stem cell homeostasis; positive regulation of receptor signaling pathway via JAK-STAT; and regulation of antibacterial peptide production. Acts upstream of with a negative effect on lymph gland crystal cell differentiation. Located in Golgi apparatus; endosome; and lysosome. Is active in mitochondrion. Is expressed in several structures, including adult head; amnioserosa primordium; embryonic/larval lymph gland; epithelium; and hemocyte. Orthologous to several human genes including OCIAD1 (OCIA domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See asrij in Genome Data Viewer
Location:
59B4-59B4; 2-101 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22886398..22887578)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18773921..18775101)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol 4-phosphate 5-kinase 59B Neighboring gene ER membrane protein complex subunit 8/9 Neighboring gene YME1 like ATPase Neighboring gene GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase Neighboring gene Mediator complex subunit 23 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The OCIAD protein family: comparative developmental biology and stem cell application. Praveen W, et al. Int J Dev Biol, 2020. PMID 32659010
  2. Expression, Purification and Crystallization of Asrij, A Novel Scaffold Transmembrane Protein. Motiwala Z, et al. J Membr Biol, 2021 Feb. PMID 33433647
  3. A Conserved Role for Asrij/OCIAD1 in Progenitor Differentiation and Lineage Specification Through Functional Interaction With the Regulators of Mitochondrial Dynamics. Ray A, et al. Front Cell Dev Biol, 2021. PMID 34295888, Free PMC Article
  4. Drosophila asrij is expressed in pole cells, trachea and hemocytes. Inamdar MS. Dev Genes Evol, 2003 Apr. PMID 12690451
  5. Differential modulation of the cellular and humoral immune responses in Drosophila is mediated by the endosomal ARF1-Asrij axis. Khadilkar RJ, et al. Sci Rep, 2017 Mar 8. PMID 28273919, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the lymph gland proteome were analyzedunder genetic conditions that either maintain precursors or promote their differentiation in vivo, by perturbing expression of Asrij, a conserved endosomal regulator of hematopoiesis.
    Title: Proteomics of Asrij Perturbation in Drosophila Lymph Glands for Identification of New Regulators of Hematopoiesis.
  2. Results show that in addition to its requirement in hematopoiesis, the ARF1-Asrij axis can differentially regulate humoral immunity in Drosophila, most likely by virtue of its endosomal function. ARF1 and Asrij bring about differential endocytic modulation of immune pathways and their depletion leads to aberrant pathway activity and an immune imbalance.
    Title: Differential modulation of the cellular and humoral immune responses in Drosophila is mediated by the endosomal ARF1-Asrij axis.
  3. ARF1-Asrij endocytic axis modulates signals that govern hematopoietic development.
    Title: ARF1-GTP regulates Asrij to provide endocytic control of Drosophila blood cell homeostasis.
  4. a role for Asrij in causing increased Notch signaling thereby affecting hemocyte differentiation
    Title: Asrij maintains the stem cell niche and controls differentiation during Drosophila lymph gland hematopoiesis.
  5. Drosophila asrij functions in the hematopoietic lineage
    Title: Drosophila asrij is expressed in pole cells, trachea and hemocytes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in embryonic hemopoiesis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hematopoietic stem cell homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_negative_effect lymph gland crystal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of antibacterial peptide production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrion organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
asrij
Names
CG13533-PA
CG13533-PB
asrij-PA
asrij-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22886398..22887578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137889.3 → NP_611733.1  asrij, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611733.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W1X9
    Related
    FBpp0071813
    Conserved Domains (1) summary
    pfam07051
    Location:21 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

  2. NM_001274214.1 → NP_001261143.1  asrij, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261143.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF31
    Conserved Domains (1) summary
    pfam07051
    Location:21 → 109
    OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KF31 A0A0B4KF31
Q9W1X9.1 Q9W1X9

Gene LinkOut

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