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stl stall [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37619, updated on 9-Dec-2024

Summary

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Official Symbol
stlprovided by FlyBase
Official Full Name
stallprovided by FlyBase
Primary source
FLYBASE:FBgn0086408
Locus tag
Dmel_CG3622
See related
AllianceGenome:FB:FBgn0086408
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GM08694; CG3622; Dmel\CG3622; fs(2)A16
Summary
Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Involved in follicle cell of egg chamber stalk formation and negative regulation of neuron migration. Predicted to be active in extracellular matrix. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome and geleophysic dysplasia 1. Orthologous to several human genes including ADAMTS10 (ADAM metallopeptidase with thrombospondin type 1 motif 10); ADAMTS16 (ADAM metallopeptidase with thrombospondin type 1 motif 16); and ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See stl in Genome Data Viewer
Location:
59B2-59B2; 2-101 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22807860..22815993)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18695365..18703498)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene bellwether Neighboring gene Cyclin B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The extracellular protease stl functions to inhibit migration of v'ch1 sensory neuron during Drosophila embryogenesis. Lhamo T, et al. Mech Dev, 2015 Aug. PMID 25953091
  2. AdamTS proteases control basement membrane heterogeneity and organ shape in Drosophila. Töpfer U, et al. Cell Rep, 2024 Jul 23. PMID 38944833
  3. stall-mediated extrinsic control of ovarian follicle formation in Drosophila. Willard SS, et al. Genetics, 2004 Sep. PMID 15454537, Free PMC Article
  4. Mosaic analysis in the drosophila ovary reveals a common hedgehog-inducible precursor stage for stalk and polar cells. Tworoger M, et al. Genetics, 1999 Feb. PMID 9927465, Free PMC Article
  5. Sol narae (Sona) is a Drosophila ADAMTS involved in Wg signaling. Kim GW, et al. Sci Rep, 2016 Aug 18. PMID 27535473, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that stl exhibits a strong mutant interaction with Delta (Dl), and Dl mutant ovaries show altered stl expression patterns.
    Title: Stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber stalk formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis HMP PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
stall
Names
CG3622-PC
CG3622-PE
female sterile(2)A16
stl-PC
stl-PE
NP_001097423.1
NP_001246469.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22807860..22815993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259540.1 → NP_001246469.1  stall, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246469.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1Z6
    Conserved Domains (4) summary
    smart00209
    Location:683 → 741
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:331 → 543
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:332 → 545
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:155 → 239
    Pep_M12B_propep; Reprolysin family propeptide

  2. NM_001103953.3 → NP_001097423.1  stall, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097423.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1Z6
    Conserved Domains (4) summary
    smart00209
    Location:683 → 741
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:331 → 543
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:332 → 545
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:155 → 239
    Pep_M12B_propep; Reprolysin family propeptide
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T3M5 Q8T3M5
Q8T458 Q8T458
Q9W1Z6 Q9W1Z6

Gene LinkOut

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