blw bellwether [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: blwprovided by FlyBase
Official Full Name: bellwetherprovided by FlyBase
Primary source: FLYBASE:FBgn0011211
Locus tag: Dmel_CG3612
See related: AllianceGenome:FB:FBgn0011211
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A2(2nd)27; ATP syn-alpha; Atp5a; ATP5a; ATP5A; ATP5alpha; ATP5F1A; ATPA; ATPA_DROME; ATPsyn-a; ATPsyn-alpha; ATPsynalpha; Blw; C-V-alpha; C-Va; CG3612; CValpha; CxV; dATP5A; Dmel\CG3612; l(2)01410; l(2)03972; l(2)59ABa; l(2)k00212; ms(2)01504; ms(2)Pry58F
Summary: Predicted to enable ADP binding activity and ATP binding activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in electron transport chain and lipid storage. Located in mitochondrion. Is expressed in adult head; adult heart; adult hemolymph; germline cell; and wing disc. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22; mitochondrial complex V (ATP synthase) deficiency nuclear type 4A; and mitochondrial complex V (ATP synthase) deficiency nuclear type 4B. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 59B2-59B2; 2-101 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22799099..22802180)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18686604..18689685)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0208 (e-PCR)
- UniSTS:13554

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ADP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATP synthase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in electron transport chain	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven ATP synthesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IEA Inferred from Electronic Annotation more info
part_of proton-transporting ATP synthase, catalytic core	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: bellwether

Names: ATP SYNTHASE ALPHA; ATP VDRC synthase F1F0; ATP synthase; ATP synthase alpha chain; ATP synthase alpha subunit of complex V; ATP synthase subunit alpha; ATP synthase subunits alpha; ATP synthase, alpha subunit; ATP synthase, subunit alpha; ATP synthetase alpha chain; CG3612-PA; COMPLEX V: alpha chain; F0/F1 ATP synthase alpha; alpha subunit of ATP synthase; alpha subunit of the mitochondrial F[[1]]F[[0]] ATPase; alpha-ATP synthase; alpha-subunit of ATP synthase; bellweather; blw-PA; colibri; complex V alpha; complex Va; complex valpha; complex valpha subunit; mitochondrial ATP synthase alpha subunit; mitochondrial ATP synthase subunit B; mitochondrial ATP synthase subunit alpha of complex V; mitochondrial ATPase complex V-subunit alpha

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

22799099..22802180

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166554.3 → NP_726243.1 bellwether [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726243.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P35381, Q53YF5, Q94512, Q9W1Z7

Related

FBpp0071794

Conserved Domains (4) summary

PRK09281
Location:46 → 552

PRK09281; F0F1 ATP synthase subunit alpha; Validated

cd01132
Location:136 → 417

F1_ATPase_alpha; F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to ...

pfam00306
Location:426 → 520

ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain

pfam02874
Location:68 → 134

ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain