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robo1 - roundabout 1

Enables heparin binding activity. Involved in several processes, including heart development; neuron projection guidance; and regulation of cell migration. Located in several cellular components, including axonal growth cone; dendrite; and neuronal cell body. Part of Slit-Robo signaling complex. Is expressed in several structures, including CNS neuron; epithelium; larval longitudinal connective; sensory neurons; and synaptic neuropil domain. Used to study myoclonic-atonic epilepsy. Human ortholog(s) of this gene implicated in congenital nystagmus (multiple); hematologic cancer (multiple); panhypopituitarism; and vesicoureteral reflux. Orthologous to several human genes including ROBO1 (roundabout guidance receptor 1). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa