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CG4752 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37569, updated on 9-Dec-2024

Summary

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Official Symbol
CG4752provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034733
Locus tag
Dmel_CG4752
See related
AllianceGenome:FB:FBgn0034733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4752
Summary
Predicted to enable 5-oxoprolinase (ATP-hydrolyzing) activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval dorsal vessel; epithelium; gastric caecum; and gut section. Orthologous to human OPLAH (5-oxoprolinase, ATP-hydrolysing). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG4752 in Genome Data Viewer
Location:
58E3-58E3; 2-100 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22478379..22483054)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18365884..18370559)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1. Zhang T, et al. J Cell Sci, 2015 Aug 1. PMID 26092939, Free PMC Article
  2. Discovery and Visualization of Age-Dependent Patterns in the Diurnal Transcriptome of Drosophila. Sebastian B, et al. J Circadian Rhythms, 2022. PMID 36561348, Free PMC Article
  3. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article
  4. A gene-specific T2A-GAL4 library for Drosophila. Lee PT, et al. Elife, 2018 Mar 22. PMID 29565247, Free PMC Article
  5. Development of a Clickable Probe for Profiling of Protein Glutathionylation in the Central Cellular Metabolism of E. coli and Drosophila. Feng S, et al. Chem Biol, 2015 Nov 19. PMID 26526100

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5-oxoprolinase (ATP-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4752-PA
NP_611675.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22478379..22483054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137831.3 → NP_611675.2  uncharacterized protein Dmel_CG4752 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611675.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS45, Q9W247
    Related
    FBpp0071743
    Conserved Domains (4) summary
    PLN02666
    Location:5 → 1262
    PLN02666; 5-oxoprolinase
    pfam01968
    Location:233 → 531
    Hydantoinase_A; Hydantoinase/oxoprolinase
    pfam02538
    Location:737 → 1259
    Hydantoinase_B; Hydantoinase B/oxoprolinase
    pfam05378
    Location:8 → 214
    Hydant_A_N; Hydantoinase/oxoprolinase N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MS45 Q8MS45
Q9W247 Q9W247

Gene LinkOut

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