qkr58E-1 quaking related 58E-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: qkr58E-1provided by FlyBase
Official Full Name: quaking related 58E-1provided by FlyBase
Primary source: FLYBASE:FBgn0022986
Locus tag: Dmel_CG3613
See related: AllianceGenome:FB:FBgn0022986
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3613; Dmel\CG3613; qkr-58-E; Qkr58E-1; QKR58E-1; qrk58E-1; qrk58E1
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult brain cell body rind; adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to several human genes including KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 58D8-58D8; 2-99 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22412556..22415518, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18300061..18303023, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of precatalytic spliceosome	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: quaking related 58E-1

Names: CG3613-PA; CG3613-PC; CG3613-PD; KH-domain; qkr58E-1-PA; qkr58E-1-PC; qkr58E-1-PD

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

22412556..22415518 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299793.1 → NP_001286722.1 quaking related 58E-1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286722.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LG88, O44435

Conserved Domains (1) summary

cd02395
Location:115 → 236

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
NM_079085.5 → NP_523809.2 quaking related 58E-1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523809.2

Status: REVIEWED

UniProtKB/TrEMBL

O44435, Q9W255

Related

FBpp0071754

Conserved Domains (1) summary

cd22384
Location:109 → 210

KH-I_KHDRBS; type I K homology (KH) RNA-binding domain found in the KH domain-containing, RNA-binding, signal transduction-associated protein (KHDRBS) family
NM_001299794.1 → NP_001286723.1 quaking related 58E-1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286723.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGB9, O44435

Conserved Domains (1) summary

cd02395
Location:115 → 236

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...