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wdp windpipe [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37548, updated on 9-Dec-2024

Summary

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Official Symbol
wdpprovided by FlyBase
Official Full Name
windpipeprovided by FlyBase
Primary source
FLYBASE:FBgn0034718
Locus tag
Dmel_CG3413
See related
AllianceGenome:FB:FBgn0034718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG30504; CG3413; CT11415; CT39092; Dmel\CG3413; Wdp
Summary
Involved in several processes, including negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of stem cell proliferation; and synaptic target recognition. Located in plasma membrane. Is expressed in several structures, including adult head; primary segmental tracheal branch primordium; and primary tracheal branch. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See wdp in Genome Data Viewer
Location:
58D3-58D3; 2-99 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22298214..22311937, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18185719..18199442, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43422 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44758 Neighboring gene long non-coding RNA:CR44756 Neighboring gene Gp150

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila windpipe codes for a leucine-rich repeat protein expressed in the developing trachea. Huff JL, et al. Mech Dev, 2002 Feb. PMID 11804792
  2. Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila. Takemura M, et al. Mol Biol Cell, 2020 Apr 1. PMID 32049582, Free PMC Article
  3. Comparative analysis of the brain transcriptome in a hyper-aggressive fruit fly, Drosophila prolongata. Kudo A, et al. Insect Biochem Mol Biol, 2017 Mar. PMID 28115271
  4. Regulation of morphogen pathways by a Drosophila chondroitin sulfate proteoglycan Windpipe. Koh WS, et al. J Cell Sci, 2023 Apr 1. PMID 36897575, Free PMC Article
  5. Neural Tissue Homeostasis and Repair Is Regulated via CS and DS Proteoglycan Motifs. Hayes AJ, et al. Front Cell Dev Biol, 2021. PMID 34409033, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of morphogen pathways by a Drosophila chondroitin sulfate proteoglycan Windpipe.
    Title: Regulation of morphogen pathways by a Drosophila chondroitin sulfate proteoglycan Windpipe.
  2. Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila.
    Title: Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila.
  3. these data led us to propose that Wdp acts as a novel negative feedback regulator of the JAK/STAT pathway in regulating intestinal homeostasis
    Title: Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation.
  4. sequence and expression analysis of a novel tracheal gene, named windpipe (wdp). wdp is identical to the predicted gene CG3413 and encodes a transmembrane, leucine-rich repeat family member. wdp transcripts appear abruptly at stage 15
    Title: Drosophila windpipe codes for a leucine-rich repeat protein expressed in the developing trachea.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic target recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trachea development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
windpipe
Names
CG3413-PA
CG3413-PB
CG3413-PC
CG3413-PD
CG3413-PE
connectin-like
wdp-PA
wdp-PB
wdp-PC
wdp-PD
wdp-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22298214..22311937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166526.2 → NP_726189.1  windpipe, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726189.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1NZE9, Q8IGN2, Q95U72, Q9W266
    Related
    FBpp0071761
    Conserved Domains (3) summary
    cd00116
    Location:31 → 176
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:73 → 93
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:112 → 169
    LRR_8; Leucine rich repeat

  2. NM_137817.3 → NP_611661.1  windpipe, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611661.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1NZE9, Q8IGN2, Q95U72, Q9W266
    Related
    FBpp0071760
    Conserved Domains (3) summary
    cd00116
    Location:31 → 176
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:73 → 93
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:112 → 169
    LRR_8; Leucine rich repeat

  3. NM_166525.2 → NP_726188.1  windpipe, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726188.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1NZE9, Q8IGN2, Q95U72, Q9W266
    Related
    FBpp0071762
    Conserved Domains (3) summary
    cd00116
    Location:31 → 176
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:73 → 93
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:112 → 169
    LRR_8; Leucine rich repeat

  4. NM_166524.2 → NP_726187.1  windpipe, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726187.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1NZE9, Q8IGN2, Q95U72, Q9W266
    Related
    FBpp0071763
    Conserved Domains (3) summary
    cd00116
    Location:31 → 176
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:73 → 93
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:112 → 169
    LRR_8; Leucine rich repeat

  5. NM_001299783.1 → NP_001286712.1  windpipe, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286712.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1NZE9, Q8IGN2, Q95U72, Q9W266
    Conserved Domains (3) summary
    cd00116
    Location:31 → 176
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:73 → 93
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:112 → 169
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W266.1 Q9W266

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