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TEX38 testis expressed 38 [ Homo sapiens (human) ]

Gene ID: 374973, updated on 27-Nov-2024

Summary

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Official Symbol
TEX38provided by HGNC
Official Full Name
testis expressed 38provided by HGNC
Primary source
HGNC:HGNC:29589
See related
Ensembl:ENSG00000186118 AllianceGenome:HGNC:29589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THEG4; C1orf223; ATPAF1-AS1
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis (RPKM 65.6) See more
Orthologs
mouse all
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Genomic context

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See TEX38 in Genome Data Viewer
Location:
1p33
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46668886..46673594)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46546126..46550834)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47137526..47139266)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378697 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47131482-47132011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47132012-47132540 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:47133653-47133823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1007 Neighboring gene EFCAB14 antisense RNA 1 Neighboring gene neudesin neurotrophic factor pseudogene 1 Neighboring gene uncharacterized LOC105378698 Neighboring gene EF-hand calcium binding domain 14 Neighboring gene Sharpr-MPRA regulatory region 7632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47193413-47194254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47194255-47195096 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:47210608-47210835 Neighboring gene uncharacterized LOC105378699

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl A, et al. Nature, 2011 Dec 1. PMID 22020285, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
testis-expressed protein 38
Names
ATPAF1 antisense RNA 1
ATPAF1 antisense gene protein 1
testis highly expressed protein 4
testis-expressed sequence 38 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145474.4 → NP_001138946.1  testis-expressed protein 38 isoform 1

    See identical proteins and their annotated locations for NP_001138946.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI828862, BC067853, BC126318
    Consensus CDS
    CCDS57999.1
    UniProtKB/Swiss-Prot
    A1A4F8, Q6PEX7
    UniProtKB/TrEMBL
    C9W8M6
    Related
    ENSP00000455854.1, ENST00000334122.5
    Conserved Domains (1) summary
    pfam15834
    Location:13 → 205
    THEG4; Testis highly expressed protein 4

  2. NM_001300863.2 → NP_001287792.1  testis-expressed protein 38 isoform 2

    See identical proteins and their annotated locations for NP_001287792.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AI828862, BC067853, BC144026
    Consensus CDS
    CCDS72780.1
    UniProtKB/TrEMBL
    B7ZLT1
    Related
    ENSP00000456524.1, ENST00000564373.1
    Conserved Domains (1) summary
    pfam15834
    Location:1 → 151
    THEG4; Testis highly expressed protein 4

  3. NM_001300864.2 → NP_001287793.1  testis-expressed protein 38 isoform 3

    See identical proteins and their annotated locations for NP_001287793.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AI828862, BC067853, BC144027
    Consensus CDS
    CCDS72781.1
    UniProtKB/TrEMBL
    B7ZLT2
    Related
    ENSP00000456892.1, ENST00000415500.1
    Conserved Domains (1) summary
    pfam15834
    Location:1 → 129
    THEG4; Testis highly expressed protein 4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    46668886..46673594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541421.4 → XP_011539723.1  testis-expressed protein 38 isoform X1

    Conserved Domains (1) summary
    pfam15834
    Location:14 → 206
    THEG4; Testis highly expressed protein 4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    46546126..46550834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336447.1 → XP_054192422.1  testis-expressed protein 38 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PEX7.3 GenPept UniProtKB/Swiss-Prot:Q6PEX7

Gene LinkOut

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