ASPP Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ASPPprovided by FlyBase
Official Full Name: Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0034606
Locus tag: Dmel_CG18375
See related: AllianceGenome:FB:FBgn0034606
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18375; dASPP; Dmel\CG18375
Summary: Enables protein tyrosine kinase activator activity. Predicted to be involved in regulation of apoptotic process. Located in adherens junction. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Orthologous to human PPP1R13B (protein phosphatase 1 regulatory subunit 13B) and TP53BP2 (tumor protein p53 binding protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 57D2-57D4; 2-94 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (21217856..21251150, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17105361..17138655, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables p53 binding	IBA Inferred from Biological aspect of Ancestor more info
enables p53 binding	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ankyrin-repeat, SH3-domain, and Proline-rich-region containing protein

Names: ASPP-PA; ASPP-PB; ASPP-PC; Ankyrin-repeat, SH3-domain and Proline-rich-region containing protein; CG18375-PA; CG18375-PB; CG18375-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

21217856..21251150 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274193.1 → NP_001261122.1 Ankyrin-repeat, SH3-domain, and Proline-rich-region containing protein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261122.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KF17, Q86PC3

Conserved Domains (4) summary

cd11807
Location:950 → 1007

SH3_ASPP; Src homology 3 domain of Apoptosis Stimulating of p53 proteins (ASPP)

cd00204
Location:818 → 919

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:820 → 906

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:820 → 846

ANK; ANK repeat [structural motif]
NM_137721.3 → NP_611565.2 Ankyrin-repeat, SH3-domain, and Proline-rich-region containing protein, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611565.2

Status: REVIEWED

UniProtKB/TrEMBL

Q86PC3, Q9W2J2

Related

FBpp0071548

Conserved Domains (4) summary

cd11807
Location:950 → 1007

SH3_ASPP; Src homology 3 domain of Apoptosis Stimulating of p53 proteins (ASPP)

cd00204
Location:818 → 919

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:820 → 906

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:820 → 846

ANK; ANK repeat [structural motif]
NM_176243.2 → NP_788423.1 Ankyrin-repeat, SH3-domain, and Proline-rich-region containing protein, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788423.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86BG1, Q86PC3

Related

FBpp0071549

Conserved Domains (4) summary

cd11807
Location:999 → 1056

SH3_ASPP; Src homology 3 domain of Apoptosis Stimulating of p53 proteins (ASPP)

cd00204
Location:867 → 968

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:869 → 955

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:869 → 895

ANK; ANK repeat [structural motif]