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Lapsyn Leucine-rich repeat activity-regulated protein at synapses [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37418, updated on 9-Dec-2024

Summary

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Official Symbol
Lapsynprovided by FlyBase
Official Full Name
Leucine-rich repeat activity-regulated protein at synapsesprovided by FlyBase
Primary source
FLYBASE:FBgn0034602
Locus tag
Dmel_CG15658
See related
AllianceGenome:FB:FBgn0034602
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15658; CT35842; Dmel\CG15658
Summary
Involved in nervous system development. Located in neuronal cell body. Colocalizes with presynaptic membrane. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; posterior ectoderm anlage; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Lapsyn in Genome Data Viewer
Location:
57C9-57D1; 2-93 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21193571..21199431)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17081076..17086936)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glycine-GCC 1-13 Neighboring gene tudor Neighboring gene uncharacterized protein Neighboring gene Glycogenin Neighboring gene UDP-glycosyltransferase family 49 member B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lapsyn controls branch extension and positioning of astrocyte-like glia in the Drosophila optic lobe. Richier B, et al. Nat Commun, 2017 Aug 22. PMID 28827667, Free PMC Article
  2. Astrocyte development-More questions than answers. Markey KM, et al. Front Cell Dev Biol, 2023. PMID 37051466, Free PMC Article
  3. Selection, recombination and demographic history in Drosophila miranda. Bachtrog D, et al. Genetics, 2006 Dec. PMID 17028331, Free PMC Article
  4. Neuron-glia interaction in the Drosophila nervous system. Bittern J, et al. Dev Neurobiol, 2021 Jul. PMID 32096904
  5. Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Brodsky MH, et al. Mol Cell Biol, 2004 Feb. PMID 14729967, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Leucine-rich repeat activity-regulated protein at synapses
Names
CG15658-PA
Lapsyn-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21193571..21199431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137717.4 → NP_611561.1  Leucine-rich repeat activity-regulated protein at synapses [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611561.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961I0, Q9W2J7
    Related
    FBpp0071509
    Conserved Domains (4) summary
    cd00116
    Location:94 → 249
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:39 → 59
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:106 → 145
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:58 → 118
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W2J7 Q9W2J7

Gene LinkOut

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