Xpd Xeroderma pigmentosum D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Xpdprovided by FlyBase
Official Full Name: Xeroderma pigmentosum Dprovided by FlyBase
Primary source: FLYBASE:FBgn0261850
Locus tag: Dmel_CG9433
See related: AllianceGenome:FB:FBgn0261850
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9433; DhR3; DhXPD; Dmel\CG9433; DmXPD; ERCC2; l(2)SH2 2137; l(2)SH2137; xpd; XPD; XPD/ERCC2
Summary: Predicted to enable 5'-3' DNA helicase activity and damaged DNA binding activity. Involved in several processes, including regulation of chromosome segregation; regulation of mitotic cell cycle; and response to UV. Located in cytoplasm; nucleus; and polytene chromosome. Part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Is expressed in embryonic cortex; embryonic/larval fat body; embryonic/larval salivary gland; and organism. Used to study Cockayne syndrome; photosensitive trichothiodystrophy; and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; acquired immunodeficiency syndrome; carcinoma (multiple); hematologic cancer (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 57C7-57C7; 2-93 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (21171001..21174504)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17058506..17062009)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ciao1 interacts with Crumbs and Xpd to regulate organ growth in Drosophila.
Title: Ciao1 interacts with Crumbs and Xpd to regulate organ growth in Drosophila.
XPD expression significantly inhibited HepG2 cell proliferation, promoted HepG2 cell apoptosis, inhibited HepG2 colony formation, decreased HepG2 cells' migratory ability, and significantly lowered HepG2 cells' invasive capacity.
Title: XPD Functions as a Tumor Suppressor and Dysregulates Autophagy in Cultured HepG2 Cells.
A novel Crb-Galla-Xpd complex and its function for proper chromosome segregation.
Title: Crumbs interacts with Xpd for nuclear division control in Drosophila.
The multitask protein Xpd also plays an essential role in cell cycle regulation that appears to be independent of transcription or nucleotide excision repair.
Title: Drosophila Xpd regulates Cdk7 localization, mitotic kinase activity, spindle dynamics, and chromosome segregation.
The variant genotypes of XPD Lys751Gln polymorphism are associated with a higher risk of esophageal adenocarcinoma.
Title: XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 5'-3' DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA polymerase II promoter clearance	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of mitotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of syncytial blastoderm mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in transcription open complex formation at RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIH core complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIH core complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of transcription factor TFIIH holo complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription factor TFIIH holo complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: xeroderma pigmentosum D

Names: CG9433-PA; Xpd-PA; lethal (2) SH2137; xeroderma pigmentosum D ortholog

NP_726036.2

EC 3.6.1.-

EC 5.6.2.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

21171001..21174504

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166429.3 → NP_726036.2 xeroderma pigmentosum D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726036.2

Status: REVIEWED

UniProtKB/TrEMBL

D3DMG9, Q7KVP9

Related

FBpp0071503

Conserved Domains (4) summary

smart00488
Location:8 → 280

DEXDc2; DEAD-like helicases superfamily

smart00491
Location:542 → 686

HELICc2; helicase superfamily c-terminal domain

TIGR00604
Location:7 → 717

rad3; DNA repair helicase (rad3)

pfam06777
Location:270 → 413

HBB; Helical and beta-bridge domain