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CG30389 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37410, updated on 4-Jan-2025

Summary

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Official Symbol
CG30389provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0050389
Locus tag
Dmel_CG30389
See related
AllianceGenome:FB:FBgn0050389
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT02070; CG10518; CG4126; Dmel\CG30389
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in chemotaxis and neuronal signal transduction. Predicted to be active in nuclear membrane and rough endoplasmic reticulum membrane. Orthologous to human MACO1 (macoilin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG30389 in Genome Data Viewer
Location:
57C4-57C6; 2-93 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21148265..21160545, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17035770..17048050, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene X box binding protein-1 Neighboring gene High mobility group protein 2 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Glycine-GCC 1-12 Neighboring gene transfer RNA:Tryptophan-CCA 2-3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Ribosomal Protein RpL22 Interacts In Vitro with 5'-UTR Sequences Found in Some Drosophila melanogaster Transposons. Minervini CF, et al. Genes (Basel), 2022 Feb 5. PMID 35205350, Free PMC Article
  2. Genome-wide RNAi screen identifies broadly-acting host factors that inhibit arbovirus infection. Yasunaga A, et al. PLoS Pathog, 2014 Feb. PMID 24550726, Free PMC Article
  3. Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila. Candia N, et al. Hum Genet, 2023 Aug. PMID 37368047
  4. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article
  5. A gain-of-function screen for genes that influence axon guidance identifies the NF-kappaB protein dorsal and reveals a requirement for the kinase Pelle in Drosophila photoreceptor axon targeting. Mindorff EN, et al. Genetics, 2007 Aug. PMID 17603113, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuronal signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuronal signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in rough endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG30389-PA
CG30389-PC
CG30389-PD
CG30389-PE
CG30389-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21148265..21160545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274189.1 → NP_001261118.1  uncharacterized protein Dmel_CG30389, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261118.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E901
    Conserved Domains (3) summary
    pfam09726
    Location:2 → 836
    Macoilin; Transmembrane protein
    pfam10211
    Location:567 → 654
    Ax_dynein_light; Axonemal dynein light chain
    cl23720
    Location:639 → 746
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. NM_137711.4 → NP_611555.2  uncharacterized protein Dmel_CG30389, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611555.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E901
    Related
    FBpp0071555
    Conserved Domains (3) summary
    pfam09726
    Location:2 → 836
    Macoilin; Transmembrane protein
    pfam10211
    Location:567 → 654
    Ax_dynein_light; Axonemal dynein light chain
    cl23720
    Location:639 → 746
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. NM_001274188.1 → NP_001261117.1  uncharacterized protein Dmel_CG30389, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261117.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFE6
    Conserved Domains (3) summary
    pfam09726
    Location:2 → 836
    Macoilin; Transmembrane protein
    pfam10211
    Location:567 → 654
    Ax_dynein_light; Axonemal dynein light chain
    cl23720
    Location:639 → 746
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  4. NM_001274187.1 → NP_001261116.1  uncharacterized protein Dmel_CG30389, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261116.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEW2
    Conserved Domains (3) summary
    pfam09726
    Location:2 → 893
    Macoilin; Transmembrane protein
    pfam10211
    Location:624 → 711
    Ax_dynein_light; Axonemal dynein light chain
    cl23720
    Location:696 → 803
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  5. NM_137712.4 → NP_611556.2  uncharacterized protein Dmel_CG30389, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611556.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E901
    Related
    FBpp0071556
    Conserved Domains (3) summary
    pfam09726
    Location:2 → 836
    Macoilin; Transmembrane protein
    pfam10211
    Location:567 → 654
    Ax_dynein_light; Axonemal dynein light chain
    cl23720
    Location:639 → 746
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEW2 A0A0B4KEW2
A0A0B4KFE6 A0A0B4KFE6
Q0E901 Q0E901
Q961P6 Q961P6

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