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CG10527 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37393, updated on 9-Dec-2024

Summary

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Official Symbol
CG10527provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034583
Locus tag
Dmel_CG10527
See related
AllianceGenome:FB:FBgn0034583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10527; FAMeT
Summary
Located in cytoplasm. Is expressed in several structures, including adult head; female germline cell; follicle cell; gland; and glial cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG10527 in Genome Data Viewer
Location:
57B16-57B16; 2-92 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21070368..21072789, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16957873..16960294, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44703 Neighboring gene Chitinase 4 Neighboring gene antisense RNA:CR44704 Neighboring gene Chitinase 9 Neighboring gene Trehalase Neighboring gene Rabaptin-5 Neighboring gene uncharacterized protein Neighboring gene Gar1 ribonucleoprotein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila CG10527 mutants are resistant to juvenile hormone and its analog methoprene. Zhang H, et al. Biochem Biophys Res Commun, 2010 Oct 15. PMID 20833126
  2. A putative farnesoic acid O-methyltransferase (FAMeT) orthologue in Drosophila melanogaster (CG10527): relationship to juvenile hormone biosynthesis? Burtenshaw SM, et al. Peptides, 2008 Feb. PMID 18242777
  3. Methyl farnesoate plays a dual role in regulating Drosophila metamorphosis. Wen D, et al. PLoS Genet, 2015 Mar. PMID 25774983, Free PMC Article
  4. Carbohydrate-binding ability of a recombinant protein containing the DM9 motif from Drosophila melanogaster. Hatakeyama T, et al. J Biochem, 2024 May 31. PMID 38324702
  5. The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. Zhang YQ, et al. Dev Biol, 2004 Jun 15. PMID 15183715

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CG10527 plays little, if any, role in juvenile hormone (JH) biosynthesis but may participate in the JH signaling pathway.
    Title: Drosophila CG10527 mutants are resistant to juvenile hormone and its analog methoprene.
  2. Data suggest that FAMeT does not have the appropiate protein domains to serve directly as a FAMeT and cannot enzymatically convert farnesoic cid to methyl farnesoate.
    Title: A putative farnesoic acid O-methyltransferase (FAMeT) orthologue in Drosophila melanogaster (CG10527): relationship to juvenile hormone biosynthesis?
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables farnesoic acid O-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG10527-PA
farnesoic acid O-methyltransferase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21070368..21072789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137700.4 → NP_611544.1  uncharacterized protein Dmel_CG10527 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611544.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MR08, Q9W2M4
    Related
    FBpp0071470
    Conserved Domains (3) summary
    smart00696
    Location:226 → 296
    DM9; Repeats found in Drosophila proteins
    pfam11901
    Location:180 → 286
    DUF3421; Protein of unknown function (DUF3421)
    pfam12248
    Location:35 → 133
    Methyltransf_FA; Farnesoic acid 0-methyl transferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MR08 Q8MR08
Q9W2M4 Q9W2M4

Gene LinkOut

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