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RIC-3 RIC3 acetylcholine receptor chaperone [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37384, updated on 9-Dec-2024

Summary

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Official Symbol
RIC-3provided by FlyBase
Official Full Name
RIC3 acetylcholine receptor chaperoneprovided by FlyBase
Primary source
FLYBASE:FBgn0050296
Locus tag
Dmel_CG30296
See related
AllianceGenome:FB:FBgn0050296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15652; CG30296; CG30926; CG9349; Dmel\CG30296; DmRIC-3; Ric3
Summary
Predicted to enable unfolded protein binding activity. Involved in chaperone-mediated protein folding and protein maturation by protein folding. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle; neuron projection; and neuronal cell body. Is expressed in adult head and adult heart. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See RIC-3 in Genome Data Viewer
Location:
57B9-57B12; 2-92 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21017784..21024918)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16905289..16912423)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene grauzone Neighboring gene uncharacterized protein Neighboring gene Souji Neighboring gene NADH dehydrogenase (ubiquinone) B14.7 subunit Neighboring gene long non-coding RNA:CR45148

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Host-cell specific effects of the nicotinic acetylcholine receptor chaperone RIC-3 revealed by a comparison of human and Drosophila RIC-3 homologues. Lansdell SJ, et al. J Neurochem, 2008 Jun. PMID 18208544
  2. Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions. Ihara M, et al. Proc Natl Acad Sci U S A, 2020 Jul 14. PMID 32611810, Free PMC Article
  3. Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors-targets of neonicotinoids. Komori Y, et al. PLoS Genet, 2023 Feb. PMID 36795653, Free PMC Article
  4. Generation of Mutants from the 57B Region of Drosophila melanogaster. Steinmetz EL, et al. Genes (Basel), 2023 Nov 6. PMID 38002990, Free PMC Article
  5. Constructing and Tuning Excitatory Cholinergic Synapses: The Multifaceted Functions of Nicotinic Acetylcholine Receptors in Drosophila Neural Development and Physiology. Rosenthal JS, et al. Front Cell Neurosci, 2021. PMID 34650404, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables unfolded protein binding IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation by protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RIC3 acetylcholine receptor chaperone
Names
CG30296-PC
CG30296-PD
CG30296-PE
CG30296-PG
CG30296-PH
CG30296-PI
CG30296-PJ
CG30296-PK
CG30296-PL
CG30296-PM
CG30296-PN
CG30296-PO
CG30296-PP
CG30296-PQ
CG30296-PR
CG30296-PS
CG30296-PT
CG30296-PU
CG30296-PV
RIC-3-PC
RIC-3-PD
RIC-3-PE
RIC-3-PG
RIC-3-PH
RIC-3-PI
RIC-3-PJ
RIC-3-PK
RIC-3-PL
RIC-3-PM
RIC-3-PN
RIC-3-PO
RIC-3-PP
RIC-3-PQ
RIC-3-PR
RIC-3-PS
RIC-3-PT
RIC-3-PU
RIC-3-PV

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21017784..21024918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103919.3 → NP_001097389.1  RIC3 acetylcholine receptor chaperone, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097389.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPP4, Q058V3
    Conserved Domains (1) summary
    pfam15361
    Location:145 → 224
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  2. NM_001274185.2 → NP_001261114.1  RIC3 acetylcholine receptor chaperone, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261114.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFX1
    Conserved Domains (1) summary
    pfam15361
    Location:145 → 224
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  3. NM_001299730.1 → NP_001286659.1  RIC3 acetylcholine receptor chaperone, isoform V [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286659.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LH23
    Conserved Domains (2) summary
    pfam15361
    Location:145 → 224
    RIC3; Resistance to inhibitors of cholinesterase homologue 3
    pfam16515
    Location:290 → 330
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

  4. NM_137693.4 → NP_611537.2  RIC3 acetylcholine receptor chaperone, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611537.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPP4, Q9W2N4
    Conserved Domains (1) summary
    pfam15361
    Location:145 → 224
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  5. NM_001169756.2 → NP_001163227.1  RIC3 acetylcholine receptor chaperone, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163227.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPP4, E1JGP2
    Conserved Domains (1) summary
    pfam15361
    Location:145 → 224
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  6. NM_001169750.2 → NP_001163221.1  RIC3 acetylcholine receptor chaperone, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163221.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPP6, E1JGP3
    Conserved Domains (1) summary
    pfam15361
    Location:145 → 224
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  7. NM_001169755.2 → NP_001163226.1  RIC3 acetylcholine receptor chaperone, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163226.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPP5, E1JGP4
    Conserved Domains (1) summary
    pfam15361
    Location:145 → 224
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  8. NM_001169752.2 → NP_001163223.1  RIC3 acetylcholine receptor chaperone, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163223.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPP9, E1JGP5
    Conserved Domains (1) summary
    pfam15361
    Location:33 → 184
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  9. NM_001169754.2 → NP_001163225.1  RIC3 acetylcholine receptor chaperone, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163225.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPP7, E1JGP6
    Conserved Domains (1) summary
    pfam15361
    Location:33 → 184
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  10. NM_001169751.2 → NP_001163222.1  RIC3 acetylcholine receptor chaperone, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163222.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPQ0, E1JGP7
    Conserved Domains (1) summary
    pfam15361
    Location:33 → 184
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  11. NM_001169753.2 → NP_001163224.1  RIC3 acetylcholine receptor chaperone, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163224.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPP8, E1JGP8
    Conserved Domains (1) summary
    pfam15361
    Location:33 → 184
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  12. NM_166418.4 → NP_726018.2  RIC3 acetylcholine receptor chaperone, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726018.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPQ3, Q9W2N3
    Conserved Domains (1) summary
    pfam15361
    Location:33 → 184
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  13. NM_001169759.2 → NP_001163230.1  RIC3 acetylcholine receptor chaperone, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163230.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPQ1, E1JGP9
    Conserved Domains (1) summary
    pfam15361
    Location:33 → 184
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  14. NM_001169757.2 → NP_001163228.1  RIC3 acetylcholine receptor chaperone, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163228.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPQ4, E1JGQ0
    Conserved Domains (1) summary
    pfam15361
    Location:33 → 184
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  15. NM_001169758.2 → NP_001163229.1  RIC3 acetylcholine receptor chaperone, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163229.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPQ2, E1JGQ1
    Conserved Domains (1) summary
    pfam15361
    Location:33 → 184
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  16. NM_206188.4 → NP_995910.2  RIC3 acetylcholine receptor chaperone, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995910.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPP9, E1JGP5
    Conserved Domains (1) summary
    pfam15361
    Location:33 → 184
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  17. NM_001103921.3 → NP_001097391.1  RIC3 acetylcholine receptor chaperone, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097391.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPP4, Q9W2N4
    Conserved Domains (1) summary
    pfam15361
    Location:145 → 224
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  18. NM_001274184.2 → NP_001261113.1  RIC3 acetylcholine receptor chaperone, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261113.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPP4, Q9W2N4
    Conserved Domains (1) summary
    pfam15361
    Location:145 → 224
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

  19. NM_001299729.1 → NP_001286658.1  RIC3 acetylcholine receptor chaperone, isoform U [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286658.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8YPP5, E1JGP4
    Conserved Domains (1) summary
    pfam15361
    Location:145 → 224
    RIC3; Resistance to inhibitors of cholinesterase homologue 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFX1 A0A0B4KFX1
A0A0B4LH23 A0A0B4LH23
E1JGP2 E1JGP2
E1JGP3 E1JGP3
E1JGP4 E1JGP4
E1JGP5 E1JGP5
E1JGP6 E1JGP6
E1JGP7 E1JGP7
E1JGP8 E1JGP8
E1JGP9 E1JGP9
E1JGQ0 E1JGQ0
E1JGQ1 E1JGQ1
Q058V3 Q058V3
Q9W2N3 Q9W2N3
Q9W2N4 Q9W2N4

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