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hand1.L heart and neural crest derivatives expressed 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 373663, updated on 4-Jan-2025

Summary

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Official Symbol
hand1.L
Official Full Name
heart and neural crest derivatives expressed 1 L homeolog
Primary source
Xenbase:XB-GENE-865344
Locus tag
XELAEV_18016946mg
See related
EnsemblRapid:ENSXLAG00005000925 AllianceGenome:Xenbase:XB-GENE-865344
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
eHAND; hand1; hand-1; hand1-A
Summary
Predicted to enable DNA binding activity and protein dimerization activity. Predicted to be located in nucleolus. Is expressed in cardiovascular system; dermal system; mesoderm; musculoskeletal system; and pharyngeal arch. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See hand1.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
2
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (28327699..28334345)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (15393542..15400396)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121401429 Neighboring gene uncharacterized LOC108710837 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC121401430 Neighboring gene SAP30-like L homeolog Neighboring gene polypeptide N-acetylgalactosaminyltransferase 10 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Xenopus eHAND: a marker for the developing cardiovascular system of the embryo that is regulated by bone morphogenetic proteins. Sparrow DB, et al. Mech Dev, 1998 Feb. PMID 9507100
  2. Asymmetrically reduced expression of hand1 homeologs involving a single nucleotide substitution in a cis-regulatory element. Ochi H, et al. Dev Biol, 2017 May 15. PMID 28359808
  3. Constitutive over-expression of VEGF results in reduced expression of Hand-1 during cardiac development in Xenopus. Nagao K, et al. Biochem Biophys Res Commun, 2007 Aug 3. PMID 17544370
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a single nucleotide substitution in the hand1.S promoter was responsible for the reduced expression in the heart.
    Title: Asymmetrically reduced expression of hand1 homeologs involving a single nucleotide substitution in a cis-regulatory element.
  2. increased vascular endothelial growth factor(170) levels disturb Hand-1 expression in the region required for normal heart morphogenesis
    Title: Constitutive over-expression of VEGF results in reduced expression of Hand-1 during cardiac development in Xenopus.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heart- and neural crest derivatives-expressed protein 1
Names
extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085659.1 → NP_001079128.1  heart- and neural crest derivatives-expressed protein 1

    See identical proteins and their annotated locations for NP_001079128.1

    Status: PROVISIONAL

    Source sequence(s)
    Z95080
    UniProtKB/Swiss-Prot
    O73615
    UniProtKB/TrEMBL
    A0A974DAM3, A0A974HQ95, B7ZRJ2
    Conserved Domains (1) summary
    cl00081
    Location:80 → 139
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    28327699..28334345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041584858.1 → XP_041440792.1  heart- and neural crest derivatives-expressed protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O73615
    UniProtKB/TrEMBL
    A0A974DAM3, A0A974HQ95, B7ZRJ2
    Related
    ENSXLAP00005002791.1, ENSXLAT00005002842.1
    Conserved Domains (1) summary
    cl00081
    Location:80 → 139
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O73615.1 GenPept UniProtKB/Swiss-Prot:O73615

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.