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Cib2 Calcium and integrin binding family member 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37363, updated on 4-Jan-2025

Summary

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Official Symbol
Cib2provided by FlyBase
Official Full Name
Calcium and integrin binding family member 2provided by FlyBase
Primary source
FLYBASE:FBgn0034558
Locus tag
Dmel_CG9236
See related
AllianceGenome:FB:FBgn0034558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9236; cib2; Dmel\CG9236
Summary
Predicted to enable calcium ion binding activity and magnesium ion binding activity. Involved in calcium ion homeostasis and phototransduction. Human ortholog(s) of this gene implicated in Usher syndrome type 1J and autosomal recessive nonsyndromic deafness 48. Orthologous to human CIB2 (calcium and integrin binding family member 2) and CIB3 (calcium and integrin binding family member 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cib2 in Genome Data Viewer
Location:
57B4-57B4; 2-92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20879930..20882663)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16767435..16770168)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Daisho2 Neighboring gene Inositol phosphate kinase 1 Neighboring gene orthopedia Neighboring gene antisense RNA:CR43160 Neighboring gene Carbonic anhydrase 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Riazuddin S, et al. Nat Genet, 2012 Nov. PMID 23023331, Free PMC Article
  2. Using Drosophila to study mechanisms of hereditary hearing loss. Li T, et al. Dis Model Mech, 2018 May 31. PMID 29853544, Free PMC Article
  3. Transgenic Drosophila lines for LexA-dependent gene and growth regulation. Chang KR, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100369, Free PMC Article
  4. The Hippo pathway promotes cell survival in response to chemical stress. Di Cara F, et al. Cell Death Differ, 2015 Sep. PMID 26021298, Free PMC Article
  5. Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors. Hall H, et al. BMC Neurosci, 2018 Jul 20. PMID 30029619, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
calcium and integrin binding family member 2
Names
CG9236-PB
CIB2 ortholog
Cib2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20879930..20882663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137679.3 → NP_611523.3  calcium and integrin binding family member 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611523.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W2Q5
    UniProtKB/TrEMBL
    C5WLR5
    Conserved Domains (1) summary
    COG5126
    Location:20 → 180
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W2Q5 Q9W2Q5

Gene LinkOut

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