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Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 373545, updated on 27-Nov-2024

Summary

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Official Symbol
Prkag2provided by RGD
Official Full Name
protein kinase AMP-activated non-catalytic subunit gamma 2provided by RGD
Primary source
RGD:727782
See related
EnsemblRapid:ENSRNOG00000009085 AllianceGenome:RGD:727782
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables AMP binding activity and protein kinase binding activity. Contributes to AMP-activated protein kinase activity. Involved in regulation of catalytic activity. Part of nucleotide-activated protein kinase complex. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 35.3), Brain (RPKM 28.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prkag2 in Genome Data Viewer
Location:
4q11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (10744695..10985939)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10010890..10252155)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (6559153..6799888)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene lysine methyltransferase 2C Neighboring gene calcineurin B homologous protein 1-like Neighboring gene hypothetical LOC100359776 Neighboring gene uncharacterized LOC102554253 Neighboring gene uncharacterized LOC102554193 Neighboring gene uncharacterized LOC120102471 Neighboring gene Ras homolog, mTORC1 binding Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A new mutation in PRKAG2 gene causing hypertrophic cardiomyopathy with conduction system disease and muscular glycogenosis. Laforêt P, et al. Neuromuscul Disord, 2006 Mar. PMID 16487706
  2. Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency. Burwinkel B, et al. Am J Hum Genet, 2005 Jun. PMID 15877279, Free PMC Article
  3. Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside. Reiter AK, et al. Am J Physiol Endocrinol Metab, 2005 May. PMID 15613684
  4. Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome. Sidhu JS, et al. Circulation, 2005 Jan 4. PMID 15611370, Free PMC Article
  5. Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy. Gollob MH, et al. Circulation, 2001 Dec 18. PMID 11748095

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ADP binding ISO
Inferred from Sequence Orthology
more info
  
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables AMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to AMP-activated protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to AMP-activated protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables cAMP-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables cAMP-dependent protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphorylase kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of carbon utilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of catalytic activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-activated protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleotide-activated protein kinase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
5'-AMP-activated protein kinase subunit gamma-2
Names
AMP-activated protein kinase gamma2 subunit
AMPK gamma 2
adenosine monophosphate-activated protein kinase gamma 2-subunit
protein kinase, AMP-activated, gamma 2 non-catalytic subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398879.1 → NP_001385808.1  5'-AMP-activated protein kinase subunit gamma-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    Conserved Domains (2) summary
    cd04618
    Location:266 → 403
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:429 → 552
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  2. NM_184051.1 → NP_908940.1  5'-AMP-activated protein kinase subunit gamma-2 isoform 2

    See identical proteins and their annotated locations for NP_908940.1

    Status: PROVISIONAL

    Source sequence(s)
    AY348865
    UniProtKB/TrEMBL
    A6KJH6, F1LM70, Q6V7V4
    Conserved Domains (3) summary
    COG0517
    Location:192 → 308
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:35 → 164
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:191 → 310
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    10744695..10985939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235951.4 → XP_006236013.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X5

    UniProtKB/TrEMBL
    A0A140UHX4, A0A8I5Y6F6
    Related
    ENSRNOP00000062361.4, ENSRNOT00000067183.5
    Conserved Domains (3) summary
    COG0517
    Location:433 → 549
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:276 → 405
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:432 → 551
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

  2. XM_063286390.1 → XP_063142460.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X8

  3. XM_063286391.1 → XP_063142461.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X9

  4. XM_006235949.4 → XP_006236011.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y6F6
    Conserved Domains (3) summary
    COG0517
    Location:433 → 549
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:276 → 405
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:432 → 551
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

  5. XM_063286389.1 → XP_063142459.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X4

  6. XM_017592729.3 → XP_017448218.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y6F6

  7. XM_017592730.3 → XP_017448219.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y6F6

  8. XM_039107960.2 → XP_038963888.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X7

    UniProtKB/TrEMBL
    A0A8I5Y6F6
    Conserved Domains (2) summary
    cd04618
    Location:218 → 355
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:381 → 479
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  9. XM_017592731.3 → XP_017448220.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y6F6

  10. XM_039107963.2 → XP_038963891.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X12

    UniProtKB/TrEMBL
    Q4QRB9
    Conserved Domains (2) summary
    cd04618
    Location:115 → 252
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:278 → 376
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  11. XM_017592732.3 → XP_017448221.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X10

  12. XM_063286392.1 → XP_063142462.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X11

  13. XM_006235955.5 → XP_006236017.2  5'-AMP-activated protein kinase subunit gamma-2 isoform X13

    UniProtKB/TrEMBL
    A0A8I5ZQR3, Q4QRB9
    Related
    ENSRNOP00000080463.1, ENSRNOT00000106083.2

  14. XM_063286393.1 → XP_063142463.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X14

  15. XM_063286396.1 → XP_063142466.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X17

  16. XM_063286398.1 → XP_063142468.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X21

    UniProtKB/TrEMBL
    F1LM70, Q6V7V4

  17. XM_063286394.1 → XP_063142464.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X15

  18. XM_063286395.1 → XP_063142465.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X16

  19. XM_063286397.1 → XP_063142467.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X20

  20. XM_063286399.1 → XP_063142469.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X22

  21. XM_063286400.1 → XP_063142470.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X23

  22. XM_039107964.2 → XP_038963892.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X18

    Conserved Domains (2) summary
    cd04618
    Location:25 → 162
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:188 → 286
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  23. XM_039107965.2 → XP_038963893.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X19

    Conserved Domains (2) summary
    cd04618
    Location:24 → 161
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:187 → 285
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
Nucleotide Protein Strain
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