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Lrt Leucine-rich tendon-specific protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37342, updated on 4-Jan-2025

Summary

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Official Symbol
Lrtprovided by FlyBase
Official Full Name
Leucine-rich tendon-specific proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034540
Locus tag
Dmel_CG11136
See related
AllianceGenome:FB:FBgn0034540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11136; CT31131; Dmel\CG11136; lrt; tartan/capricious-like
Summary
Involved in Roundabout signaling pathway and negative regulation of muscle cell chemotaxis toward tendon cell. Located in muscle tendon junction and plasma membrane. Part of protein-containing complex. Is expressed in several structures, including amnioserosa; amnioserosa anlage; anlage in statu nascendi; epidermis; and head epidermis primordium. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Lrt in Genome Data Viewer
Location:
57A9-57A9; 2-91 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20646360..20661070)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16533865..16548575)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit K Neighboring gene Threonyl-carbamoyl synthesis 1 Neighboring gene DNA methyltransferase 1 associated protein 1 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Tryptophan-CCA 1-1 Neighboring gene transfer RNA:Tryptophan-CCA 1-2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fem-1 Neighboring gene exuperantia Neighboring gene galla-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fine tuning cellular recognition: The function of the leucine rich repeat (LRR) trans-membrane protein, LRT, in muscle targeting to tendon cells. Gilsohn E, et al. Cell Adh Migr, 2010 Jul-Sep. PMID 20404543, Free PMC Article
  2. Slit2 Promotes Angiogenic Activity Via the Robo1-VEGFR2-ERK1/2 Pathway in Both In Vivo and In Vitro Studies. Li S, et al. Invest Ophthalmol Vis Sci, 2015 Aug. PMID 26244297
  3. On the genomic location of the exuperantia1 gene in Drosophila miranda: the limits of in situ hybridization experiments. Bachtrog D, et al. Genetics, 2003 Jul. PMID 12871928, Free PMC Article
  4. LRT, a tendon-specific leucine-rich repeat protein, promotes muscle-tendon targeting through its interaction with Robo. Wayburn B, et al. Development, 2009 Nov. PMID 19793885
  5. Mechanical Control of Myotendinous Junction Formation and Tendon Differentiation during Development. Valdivia M, et al. Front Cell Dev Biol, 2017. PMID 28386542, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Slit2 may promote angiogenesis by upregulating Robo1 and activating the VEGFR2-ERK1/2 pathway.
    Title: Slit2 Promotes Angiogenic Activity Via the Robo1-VEGFR2-ERK1/2 Pathway in Both In Vivo and In Vitro Studies.
  2. These results suggest a novel mechanism of intercellular recognition through interactions between LRR family members and Robo receptors.
    Title: Fine tuning cellular recognition: The function of the leucine rich repeat (LRR) trans-membrane protein, LRT, in muscle targeting to tendon cells.
  3. Due to its distribution CG11136 protein was named ;Leucine-rich tendon-specific protein' (LRT); study shows that LRT forms a protein complex with Robo, these proteins interact, thereby affecting the extent of muscle extension towards tendon cells.
    Title: LRT, a tendon-specific leucine-rich repeat protein, promotes muscle-tendon targeting through its interaction with Robo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Roundabout signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of muscle cell chemotaxis toward tendon cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in muscle tendon junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Leucine-rich tendon-specific protein
Names
CG11136-PB
CG11136-PC
Lrt-PB
Lrt-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20646360..20661070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137662.4 → NP_611506.2  Leucine-rich tendon-specific protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611506.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBX8, E3CTT8
    Conserved Domains (5) summary
    smart00082
    Location:454 → 504
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:248 → 457
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:157 → 177
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:227 → 250
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:348 → 406
    LRR_8; Leucine rich repeat

  2. NM_001299711.1 → NP_001286640.1  Leucine-rich tendon-specific protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286640.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQL1, E3CTT8
    Conserved Domains (5) summary
    smart00082
    Location:476 → 526
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:270 → 479
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:179 → 199
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:249 → 272
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:370 → 428
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZBX8 A1ZBX8
D0IQL1 D0IQL1

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