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rig rigor mortis [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37335, updated on 4-Jan-2025

Summary

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Official Symbol
rigprovided by FlyBase
Official Full Name
rigor mortisprovided by FlyBase
Primary source
FLYBASE:FBgn0250850
Locus tag
Dmel_CG30149
See related
AllianceGenome:FB:FBgn0250850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-SAGE:Wang-132; CG11171; CG13440; CG30149; Dmel\CG30149; Gem5; Gemin5; l(2)05056; Rig
Summary
Predicted to enable mRNA 3'-UTR binding activity. Involved in flight behavior; molting cycle; and response to ecdysone. Located in cytoplasm and nucleus. Part of SMN complex and cytoplasmic U snRNP body. Is expressed in adult head; nurse cell; and oocyte. Used to study neurodevelopmental disorder with cerebellar atrophy and motor dysfunction. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cerebellar atrophy and motor dysfunction. Orthologous to human GEMIN5 (gem nuclear organelle associated protein 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See rig in Genome Data Viewer
Location:
57A8-57A8; 2-91 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20633876..20640681, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16521381..16528186, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Family with sequence similarity 21 Neighboring gene Reduction in Cnn dots 6 Neighboring gene uncharacterized protein Neighboring gene maf-S Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit K Neighboring gene Threonyl-carbamoyl synthesis 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder. Kour S, et al. Nat Commun, 2021 May 7. PMID 33963192, Free PMC Article
  2. Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila. Borg RM, et al. PLoS One, 2015. PMID 26098872, Free PMC Article
  3. The Gemin associates of survival motor neuron are required for motor function in Drosophila. Borg R, et al. PLoS One, 2013. PMID 24391840, Free PMC Article
  4. U bodies respond to nutrient stress in Drosophila. Buckingham M, et al. Exp Cell Res, 2011 Dec 10. PMID 21939654
  5. Gemin3 is an essential gene required for larval motor function and pupation in Drosophila. Shpargel KB, et al. Mol Biol Cell, 2009 Jan. PMID 18923150, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynamic intracellular redistribution of Rig protein suggests that it may act to refine spatial and temporal responses to ecdysone during development.
    Title: rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flight behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in molting cycle, chitin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ecdysone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal snRNP assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SMN complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SMN complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SMN complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytoplasmic U snRNP body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rigor mortis
Names
CG30149-PB
Gemin5
anon-SAGE:Wang-132
rig-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20633876..20640681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137655.3 → NP_611499.3  rigor mortis [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611499.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86BY9, Q86P78, Q9V957
    Related
    FBpp0085564
    Conserved Domains (3) summary
    COG2319
    Location:434 → 821
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:617 → 654
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:613 → 874
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86BY9.1 Q86BY9

Gene LinkOut

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