hif1an hypoxia inducible factor 1 subunit alpha inhibitor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hif1anprovided by ZNC
Official Full Name: hypoxia inducible factor 1 subunit alpha inhibitorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030826-19
See related: Ensembl:ENSDARG00000031915 AllianceGenome:ZFIN:ZDB-GENE-030826-19
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb728; id:ibd5139
Summary: Predicted to enable several functions, including 2-oxoglutarate-dependent dioxygenase activity; protein homodimerization activity; and transition metal ion binding activity. Acts upstream of or within negative regulation of vasculature development and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alar plate midbrain region; central nervous system; immature eye; midbrain hindbrain boundary neural rod; and midbrain neural keel. Orthologous to human HIF1AN (hypoxia inducible factor 1 subunit alpha inhibitor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (29952633..29980215, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (29822183..29849765, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish.
Title: Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables [protein]-asparagine 3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables [protein]-asparagine 3-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables [protein]-asparagine 3-dioxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables carboxylic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-aspartic acid 3-dioxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptidyl-histidine dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-histidine dioxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of vasculature development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
colocalizes_with nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: hypoxia-inducible factor 1-alpha inhibitor

Names: fih1; hypoxia inducible factor 1, alpha subunit inhibitor; hypoxia-inducible factor asparagine hydroxylase

NP_958904.1

EC 1.14.11.30

EC 1.14.11.n4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.